Su173 SALIVARY MICROBIOME COMPOSITION IS ASSOCIATED WITH ADVANCED NEOPLASIA IN BARRETT'S ESOPHAGUS INDEPENDENT OF TOOTH LOSS

Solfisburg, Quinn S.; Baldwin-Hunter, Brittany L.; Lightdale, Charles J.; Korem, Tal; Abrams, Julian A.

doi:10.1016/s0016-5085(21)02228-9

Cited by 2 publications

(1 citation statement)

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“…Some researchers have used microbiome metabolic models to predict significant changes in the metabolic capacities of the oral microbiome, including an increase in L-lactic acid and a decrease in butyric acid and L-tryptophan production. L-lactic acid has been identified as a primary energy source for advanced tumors, as it activates hypoxia-inducing factors, thereby facilitating tumor characteristics like proliferation and angiogenesis [ 216 ]. On the other hand, butyric acid potentially exerts its influence through diverse mechanisms, including modulating cancer cell growth and apoptosis, regulating immune responses, and functioning as an epigenetic regulatory molecule [ 217 , 218 ].…”

Section: Oral Microbiome and Esophageal Diseasesmentioning

confidence: 99%

The oral microbiome and oral and upper gastrointestinal diseases

Liu,

Wang,

Zhang

et al. 2024

Journal of Oral Microbiology

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Background Microbiomes are essential components of the human body, and their populations are substantial. Under normal circumstances, microbiomes coexist harmoniously with the human body, but disturbances in this equilibrium can lead to various diseases. The oral microbiome is involved in the occurrence and development of many oral and gastrointestinal diseases. This review focuses on the relationship between oral microbiomes and oral and upper gastrointestinal diseases, and therapeutic strategies aiming to provide valuable insights for clinical prevention and treatment. Methods To identify relevant studies, we conducted searches in PubMed, Google Scholar, and Web of Science using keywords such as “oral microbiome,” “oral flora, ” “gastrointestinal disease, ” without any date restrictions. Subsequently, the retrieved publications were subject to a narrative review. Results In this review, we found that oral microbiomes are closely related to oral and gastrointestinal diseases such as periodontitis, dental caries, reflux esophagitis, gastritis, and upper gastrointestinal tumors (mainly the malignant ones). Oral samples like saliva and buccal mucosa are not only easy to collect, but also display superior sample stability compared to gastrointestinal tissues. Consequently, analysis of the oral microbiome could potentially serve as an efficient preliminary screening method for high-risk groups before undergoing endoscopic examination. Besides, treatments based on the oral microbiomes could aid early diagnosis and treatment of these diseases. Conclusions Oral microbiomes are essential to oral and gastrointestinal diseases. Therapies centered on the oral microbiomes could facilitate the early detection and management of these conditions.

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Section: Oral Microbiome and Esophageal Diseasesmentioning

confidence: 99%