Su1668 Risk Factors for the Development of Sessile Serrated Adenomas in a Predominantly African-American, Female, Obese Inner City Population

Pietrak, Stanley; Kang, Mitchell; Patel, Dhruvan; Colangelo, Tim; Ahmad, Asyia S.

doi:10.1016/j.gie.2017.03.897

Cited by 1 publication

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“…A study comparing the prevalence of SSAs in Caucasian and Chinese populations also found that SSAs were more common in Caucasians than Chinese (7% versus 2%; p = 0.001) [ 21 ]. This would imply that “serrated pathway” might be largely responsible for incident and interval CRC in Caucasians compared to other race or ethnic groups [ 21 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Proximal Sessile Serrated Adenomas Are More Prevalent in Caucasians, and Gastroenterologists Are Better Than Nongastroenterologists at Their Detection

Parikh

Muthukuru

Jobanputra

et al. 2017

Gastroenterology Research and Practice

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Background and Aim Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods Patients ≥ 50 years of age undergoing a screening colonoscopy between 2012 and 2014 were included. Detection rates based on patient gender, race, colonoscopy timing, fellow participation, bowel preparation quality, and specialty of the endoscopist were calculated. t-tests were used to compare detection rates and a multivariate-adjusted analysis was performed. Results 140 PSSAs were detected from 4151 colonoscopies, with a prevalence of 3.4%. Detection rate was higher in Caucasians compared to African-Americans (AA) (3.7 ± 4.1 versus 0.96 ± 3.5; p < 0.001). Gastroenterologists detected more PSSAs compared to nongastroenterologists (3.9 ± 3.5 versus 2.2 ± 3.0; p = 0.028). These findings were still significant after adjusted multivariate analysis. The rest of the factors did not make significant difference in PSSA detection rate. Conclusions PSSAs are more prevalent in Caucasians compared to AAs. Racial difference in prevalence of PSSAs is intriguing and warrants further investigation. Gastroenterologists have a significantly higher PSSADR compared to nongastroenterologists. Educational measures should be implemented in nongastroenterologists to improve their PSSA detection rates.

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