Su1659 - A Randomized, Controlled, Single-Blind, Cross-Over Study Assessing the Effect of Green Kiwifruit on Digestive Functions and Microbiota in Constipated Patients

Cremon, Cesare; Ansell, Juliet; Pagano, Isabella; Kuhn-Sherlock, B.; Drummond, Lynley; Barbaro, Maria Raffaella; Capelli, Eleonora; Bellacosa, Lara; Stanghellini, Vincenzo; Barbara, Giovanni

doi:10.1016/s0016-5085(18)32081-x

Cited by 4 publications

(2 citation statements)

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“…In one study, stool consistency significantly decreased in the kiwifruit group when compared with the fibre group [32]: this may be due to other biochemical components of kiwifruits (water, vitamins, and minerals), which can positively influence gut health, hydration, and increase faecal volume. Results of two clinical trials briefly described in conference proceedings appeared in line with that stated above, thus underscoring once more that kiwifruit consumption can improve stool frequency in healthy volunteers and promote digestive functions in patients with constipation [40,41]. Available study results describe the effects of regular kiwifruit consumption, when, for example, a minimum of two fruits are eaten on a daily basis for several weeks, while no data were retrieved for intestinal effects due to occasional intake.…”

Section: A Critical Overview Of Qualitative-quantitative Evidencementioning

confidence: 63%

Kiwifruit (Actinidia spp.) Dietary Consumption for Constipation: A Systematic Review and Meta-Analysis

Antonelli

Donelli

2021

Future Pharmacology

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The aim of this systematic review is to understand if kiwifruit dietary consumption can effectively improve constipation and intestinal function. PubMed, EMBASE, and Cochrane Library were systematically searched for relevant studies from inception up to September 2021. After database search, nine clinical studies were considered eligible for inclusion. Most trials were characterised by a limited number of study participants (median: 20, min: 11, max: 79) and had a cross-over design. On average, study participants ate from two to four kiwifruits a day for a period varying from three days to four weeks. Included trials almost exclusively involved young or middle-aged adults with a high female-to-male ratio, whereas direct evidence for elderly people (>65 years old) is scant. Moderate quality evidence indicated that kiwifruit dietary consumption can improve complete bowel movements per week and decrease stool consistency in both healthy subjects and patients with constipation due to irritable bowel syndrome, probably owing to the fruit fibre and water content. Kiwifruit dietary consumption can also have beneficial effects beyond intestinal motility, such as a mild anti-inflammatory and antioxidant effect on the gut barrier, due to a combined activity of all its nutrients (enzymes, vitamins, minerals). When only patients affected by constipation were considered, kiwifruit consumption was likely associated with a short-term significant increase in defecation frequency but not always with significant changes in stool consistency. These results were also supported by studies characterised by the highest methodological quality and confirmed by the meta-analysis about the effects of kiwifruit-based interventions on defecation frequency (g = 0.576; 95% CI: (0.174; 0.978); p = 0.012). Further investigations on the topic are recommended to strengthen the consistency of current evidence with larger trials.

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Section: A Critical Overview Of Qualitative-quantitative Evidencementioning

confidence: 63%

Kiwifruit (Actinidia spp.) Dietary Consumption for Constipation: A Systematic Review and Meta-Analysis

Antonelli

Donelli

2021

Future Pharmacology

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“…A human intervention trial with green kiwifruit in Italian participants with Irritable Bowel Syndrome constipation type (IBS‐C) assessed the effect on the composition of the faecal microbiota. After intervention, kiwifruit significantly reduced Clostridiaceae and Streptococcaceae in patients with IBS‐C, while both kiwifruit and psyllium significantly increased the levels of Lachnospiraceae in patients with IBS‐C (Cremon et al ). These findings showed that kiwi fruit consumption could alter microbial composition; however, direct evidence of any improved health outcome remains outstanding.…”

Section: Sources Of Prebioticsmentioning

confidence: 99%

Developments in understanding and applying prebiotics in research and practice—an ISAPP conference paper

Scott

Grimaldi

Cunningham³

et al. 2019

J Appl Microbiol

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Aims The concept of using specific dietary components to selectively modulate the gut microbiota to confer a health benefit, defined as prebiotics, originated in 1995. In 2018, a group of scientists met at the International Scientific Association for Probiotics and Prebiotics annual meeting in Singapore to discuss advances in the prebiotic field, focussing on issues affecting functionality, research methodology and geographical differences. Methods and Results The discussion ranged from examining scientific literature supporting the efficacy of established prebiotics, to the prospects for establishing health benefits associated with novel compounds, isolated from different sources. Conclusions While many promising candidate prebiotics from across the globe have been highlighted in preliminary research, there are a limited number with both demonstrated mechanism of action and defined health benefits as required to meet the prebiotic definition. Prebiotics are part of a food industry with increasing market sales, yet there are great disparities in regulations in different countries. Identification and commercialization of new prebiotics with unique health benefits means that regulation must improve and remain up‐to‐date so as not to risk stifling research with potential health benefits for humans and other animals. Significance and Impact of Study This summary of the workshop discussions indicates potential avenues for expanding the range of prebiotic substrates, delivery methods to enhance health benefits for the end consumer and guidance to better elucidate their activities in human studies.

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Kiwifruit (Actinidia spp.): A review of chemical diversity and biological activities

2021

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Su1659 - A Randomized, Controlled, Single-Blind, Cross-Over Study Assessing the Effect of Green Kiwifruit on Digestive Functions and Microbiota in Constipated Patients

Cited by 4 publications

References 0 publications

Kiwifruit (Actinidia spp.) Dietary Consumption for Constipation: A Systematic Review and Meta-Analysis

Kiwifruit (Actinidia spp.) Dietary Consumption for Constipation: A Systematic Review and Meta-Analysis

Developments in understanding and applying prebiotics in research and practice—an ISAPP conference paper

Kiwifruit (Actinidia spp.): A review of chemical diversity and biological activities

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