Su1631 INGESTIBLE GAS-SENSING CAPSULE FOR WHOLE GUT TRANSIT: PROSPECTIVE COMPARISON WITH WIRELESS PH-MOTILITY CAPSULE (SMARTPILL) IN GASTROPARESIS AND CHRONIC CONSTIPATION.

Zhou, Jerry; Berean, Kyle J.; Pedersen, Holly F.; Thwaites, Phoebe A; Gibson, Peter R; Burgell, Rebecca; Ho, Vincent

doi:10.1016/s0016-5085(23)02468-x

Cited by 1 publication

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“…Measurements are transmitted from the capsule at a frequency of 434 MHz to a patient‐worn data receiver and subsequently uploaded to a remote server via a mobile device application for analysis and review via a web portal. It has been demonstrated to assess major gastrointestinal landmarks accurately in healthy subjects and a pilot study of gastroparesis and slow transit constipation and is being validated in larger trials for transit assessment presently 75,97 . Analysis of gas profiles may also enable additional physiological processes to be described, including colonic fermentation 74 and small intestinal bacterial overgrowth (SIBO) 98 .…”

Section: The Landscape Of Ingestible Sensors In Gastroenterologymentioning

confidence: 99%

Review article: Current status and future directions of ingestible electronic devices in gastroenterology

Thwaites,

Yao,

Halmos

et al. 2024

Aliment Pharmacol Ther

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SummaryBackgroundAdvances in microelectronics have greatly expanded the capabilities and clinical potential of ingestible electronic devices.AimTo provide an overview of the structure and potential impact of ingestible devices in development that are relevant to the gastrointestinal tract.MethodsWe performed a detailed literature search to inform this narrative review.ResultsTechnical success of ingestible electronic devices relies on the ability to miniaturise the microelectronic circuits, sensors and components for interventional functions while being sufficiently powered to fulfil the intended function. These devices offer the advantages of being convenient and minimally invasive, with real‐time assessment often possible and with minimal interference to normal physiology. Safety has not been a limitation, but defining and controlling device location in the gastrointestinal tract remains challenging. The success of capsule endoscopy has buoyed enthusiasm for the concepts, but few ingestible devices have reached clinical practice to date, partly due to the novelty of the information they provide and also due to the challenges of adding this novel technology to established clinical paradigms. Nonetheless, with ongoing technological advancement and as understanding of their potential impact emerges, acceptance of such technology will grow. These devices have the capacity to provide unique insight into gastrointestinal physiology and pathophysiology. Interventional functions, such as sampling of tissue or luminal contents and delivery of therapies, may further enhance their ability to sharpen gastroenterological diagnoses, monitoring and treatment.ConclusionsThe development of miniaturised ingestible microelectronic‐based devices offers exciting prospects for enhancing gastroenterological research and the delivery of personalised, point‐of‐care medicine.

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Section: The Landscape Of Ingestible Sensors In Gastroenterologymentioning

confidence: 99%