Su1169: MAST CELL ESOPHAGITIS: A NOVEL ENTITY IN PATIENTS WITH UNEXPLAINED ESOPHAGEAL SYMPTOMS

Ocampo, Adolfo A.; Genta, Robert M.; Dellon, Evan S.

doi:10.1016/s0016-5085(22)61258-7

Cited by 1 publication

(2 citation statements)

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“…More recently, a non-EoE esophagitis with marked mast cell infiltration has been observed and the entity of mast cell esophagitis has been proposed. This observation has been described in 87 patients and published in abstract form [ 83 ]. All of these patients presented with symptoms of esophageal dysfunction (mainly dysphagia and heartburn but also chest pain) but had otherwise normal endoscopy and histology.…”

Section: Mast Cell Esophagitismentioning

confidence: 64%

“…All of these patients presented with symptoms of esophageal dysfunction (mainly dysphagia and heartburn but also chest pain) but had otherwise normal endoscopy and histology. However, tryptase staining revealed a considerable mast cell infiltration in 60% of the patients (>15 mast cells per hpf) [ 83 ]. This is of particular interest given the fact that mast cells were not much increased in the case series on EoE-like disease and EoE variants.…”

Section: Mast Cell Esophagitismentioning

confidence: 99%

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Eosinophilic Esophagitis beyond Eosinophils – an Emerging Phenomenon Overlapping with Eosinophilic Esophagitis: Collegium Internationale Allergologicum (CIA) Update 2023

Nunes¹,

Straumann²,

Nunes³

et al. 2023

Int Arch Allergy Immunol

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Having long been considered the mainstay in eosinophilic esophagitis (EoE) diagnosis and pathogenesis, the role of eosinophils has been questioned and might be less important than previously thought. It is well known now that EoE is a Th2-mediated disease with many more disease features than eosinophilic infiltration. With more knowledge on EoE, less pronounced phenotypes or nuances of the disease have become apparent. In fact, EoE might be only the tip of the iceberg (and the most extreme phenotype) with several variant forms, at least three, lying on a disease spectrum. Although a common (food induced) pathogenesis has yet to be confirmed, gastroenterologists and allergologists should be aware of these new phenomena in order to further characterize these patients. In the following review, we discuss the pathogenesis of EoE, particularly those mechanisms beyond eosinophilic infiltration of the esophageal mucosa, non-eosinophilic inflammatory cell populations, the new disease entity EoE-like disease, variant forms of EoE, and the recently coined term mast cell esophagitis.

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Section: Mast Cell Esophagitismentioning

confidence: 64%

Section: Mast Cell Esophagitismentioning

confidence: 99%