Su1076 Influence of ITPA Genotype Polymorphisms on Treatment Outcome and Anemia in Chronic HCV-4 Infection

Swaff, Reham Al; Monis, Ahmed; Alanain, Essam Abu

doi:10.1016/s0016-5085(14)63567-8

Cited by 1 publication

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“…In addition, ITPA rs7270101 is an independent predictor of anaemia at week 12 only. The data concerning ITPA rs1127354 confirm previous reports 13,15,16 about the significant role of this polymorphism among the Egyptians. Ribavirin transporters play a definite role in intestinal absorption of the drug and its entry into the erythrocytes.…”

Section: Significant Association Between Non-functional Itpa Gene Varsupporting

confidence: 88%

“…15 Although ITPA rs7270101 is polymorphic in Egyptians, ITPA rs7270101 AC/CC genotypes are not significantly associated with Hb reduction throughout the 12 weeks; a finding that agrees with a previous Egyptian study. 16 The results of the present study show that the ITPA rs1127354 is an independent predictor of anaemia in Egyptian patients during the first 3 months of treatment. In addition, ITPA rs7270101 is an independent predictor of anaemia at week 12 only.…”

Section: Significant Association Between Non-functional Itpa Gene Varsupporting

confidence: 49%

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The role of ITPA and ribavirin transporter genes polymorphisms in prediction of ribavirin‐induced anaemia in chronic hepatitis C Egyptian patients

Desoky

Abdelhafez

Cusato

et al. 2017

Clin Exp Pharma Physio

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Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anaemia among Egyptians with chronic hepatitis C (CHC). Genotyping of three ITPA gene variants and two variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-α/ribavirin treatment. The baseline haemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anaemia at 4, 8 and 12 weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anaemia after 12 weeks of therapy. In conclusion, the ITPA variant rs1127354C>A significantly predict RBV-induced anaemia during the first 3 months of treatment and it is recommended to be assessed before RBV administration.

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Section: Significant Association Between Non-functional Itpa Gene Varsupporting

confidence: 88%

Section: Significant Association Between Non-functional Itpa Gene Varsupporting

confidence: 49%

The role of ITPA and ribavirin transporter genes polymorphisms in prediction of ribavirin‐induced anaemia in chronic hepatitis C Egyptian patients

Desoky

Abdelhafez

Cusato

et al. 2017

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

Su1076 Influence of ITPA Genotype Polymorphisms on Treatment Outcome and Anemia in Chronic HCV-4 Infection

Cited by 1 publication

References 0 publications

The role of ITPA and ribavirin transporter genes polymorphisms in prediction of ribavirin‐induced anaemia in chronic hepatitis C Egyptian patients

The role of ITPA and ribavirin transporter genes polymorphisms in prediction of ribavirin‐induced anaemia in chronic hepatitis C Egyptian patients

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