“…Whilst there are numerous publications related to tube voltage reduction and recommendations for this during pediatric CT examination, especially for newborn patients [14,29], only a limited number of studies have tested the impact of tube voltage and tube current modulation combined in pediatric CT practice. Tube current modulation is, however, a tool readily available on the majority of CT scanners and there have been numerous papers related to this single form of modulation [30,31]. This technique was available at the participating clinical center; however, its application was not used as increased radiation dose had resulted once employed in practice as the modulation curves were not tailored to children.…”