SU‐E‐I‐39: Molecular Image Guided Cancer Stem Cells Therapy

Abstract

Purpose:Cancer stem cells resistance to radiation is a problematic issue that has caused a big fail in cancer treatment.Methods:As a primary work, molecular imaging can indicate the main mechanisms of radiation resistance of cancer stem cells. By developing and commissioning new probes and nanomolecules and biomarkers, radiation scientist will able to identify the essential pathways of radiation resistance of cancer stem cells. As the second solution, molecular imaging is a best way to find biological target volume and delineate cancer stem cell tissues. In the other hand, by molecular imaging techniques one can image the treatment response in tumor and also in normal tissue. In this issue, the response of cancer stem cells to radiation during therapy course can be imaged, also the main mechanisms of radiation resistance and finding the best radiation modifiers (sensitizers) can be achieved by molecular imaging modalities. In adaptive radiotherapy the molecular imaging plays a vital role to have higher tumor control probability by delivering high radiation doses to cancer stem cells in any time of treatment. The outcome of a feasible treatment is dependent to high cancer stem cells response to radiation and removing all of which, so a good imaging modality can show this issue and preventing of tumor recurrence and metastasis.Results:Our results are dependent to use of molecular imaging as a new modality in the clinic. We propose molecular imaging as a new radiobiological technique to solve radiation therapy problems due to cancer stem cells.Conclusion:Molecular imaging guided cancer stem cell diagnosis and therapy is a new approach in the field of cancer treatment. This new radiobiological imaging technique should be developed in all clinics as a feasible tool that is more biological than physical imaging.

Molecular imaging in tracking cancer stem cells: A review

“…CSCs imaging is a new approach that can identify the mechanisms of resistance of CSCs to treatment, response to therapy, and predict the outcome of therapy, as well as prognosis. On the other hand, MI can explore CSCs biology (23). Various imaging modalities have been investigated for in vivo imaging of CSCs such as PET, SPECT, MRI, and OI modalities, including BLI, FMT, and nearinfrared (NIR) fluorescence reflectance imaging, and have shown interesting results for in vivo imaging of CSCs.…”