SU-D-18A-02: Towards Real-Time On-Board Volumetric Image Reconstruction for Intrafraction Target Verification in Radiation Therapy

Xu, Xiaolei; Iliopoulos, Alexandros-Stavros; Zhang, Y; Pitsianis, Nikos P.; Sun, Xiaobai; Yin, Fang‐Fang; Ren, Lei

doi:10.1118/1.4887902

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“…The acceleration of the optimization speed through software-based restructuring and hardware-based GPU [44, 45] computation is under progress. A preliminary version of the accelerated code has already achieved a computation speed of around 70 times faster [46]. …”

Section: Discussionmentioning

confidence: 99%

Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections

You

Yin

Pan

et al. 2015

Radiotherapy and Oncology

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Background and Purpose A new technique has been previously reported to estimate high-quality 4D-CBCT using prior information and limited-angle projections. This study is to investigate its clinical feasibility through both phantom and patient studies. Materials and Methods The new technique used to estimate 4D-CBCT is called MMFD-NCC. It is based on the previously reported motion-modeling and free-form deformation (MMFD) method, with the introduction of normalized-cross-correlation (NCC) as a new similarity metric. The clinical feasibility of this technique was evaluated by assessing the accuracy of estimated anatomical structures in comparison to those in the ‘ground-truth’ reference 4D-CBCT, using data obtained from a physical phantom and three lung cancer patients. Both volume percentage error (VPE) and center-of-mass error (COME) of the estimated tumor volume were used as the evaluation metrics. Results The average VPE/COME of the tumor in the prior image was 257.1%/10.1 mm for the phantom study and 55.6%/3.8 mm for the patient study. Using only orthogonal-view 30° projections, the MMFD-NCC has reduced the corresponding values to 7.7% /1.2 mm and 9.6%/1.1 mm, respectively. Conclusions The MMFD-NCC technique is able to estimate 4D-CBCT images with geometrical accuracy of the tumor within 10% VPE and 2 mm COME, which can be used to improve the localization accuracy of radiotherapy.

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Section: Discussionmentioning

confidence: 99%