SU-8 free-standing microfluidic probes

Kim, Anna A.; Kustanovich, Kiryl; Baratian, Davood; Ainla, Alar; Shaali, Mehrnaz; Jeffries, Gavin D. M.; Jesorka, Aldo

doi:10.1063/1.4975026

Cited by 12 publications

(7 citation statements)

References 42 publications

(35 reference statements)

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“…Optical lithography-based methods have been extensively used for the fabrication of microfluidic channels. SU-8 is one of the most popular materials in this method as it has high mechanical rigidity, and chemical stability, as well as a defined shape and size [ 68 ]. SU-8 has also been used for the fabrication of masters of in-line micro-valves with different aspect ratios via lithography techniques due to its chemical and thermal stability after polymerization and allows mass production from a single master mold [ 69 ].…”

Section: Polymer and Paper-based Microfluidic Fabrication Methodsmentioning

confidence: 99%

Polymeric and Paper-Based Lab-on-a-Chip Devices in Food Safety: A Review

2023

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Food quality and safety are important to protect consumers from foodborne illnesses. Currently, laboratory scale analysis, which takes several days to complete, is the main way to ensure the absence of pathogenic microorganisms in a wide range of food products. However, new methods such as PCR, ELISA, or even accelerated plate culture tests have been proposed for the rapid detection of pathogens. Lab-on-chip (LOC) devices and microfluidics are miniaturized devices that can enable faster, easier, and at the point of interest analysis. Nowadays, methods such as PCR are often coupled with microfluidics, providing new LOC devices that can replace or complement the standard methods by offering highly sensitive, fast, and on-site analysis. This review’s objective is to present an overview of recent advances in LOCs used for the identification of the most prevalent foodborne and waterborne pathogens that put consumer health at risk. In particular, the paper is organized as follows: first, we discuss the main fabrication methods of microfluidics as well as the most popular materials used, and then we present recent literature examples for LOCs used for the detection of pathogenic bacteria found in water and other food samples. In the final section, we summarize our findings and also provide our point of view on the challenges and opportunities in the field.

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Section: Polymer and Paper-based Microfluidic Fabrication Methodsmentioning

confidence: 99%

Polymeric and Paper-Based Lab-on-a-Chip Devices in Food Safety: A Review

2023

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“…polymer and paper. Currently, more organic and inorganic materials have been used in the fabrication of low-cost microfluidics such as elastomers [20], thermal plastics [21], thermoset [22], paper [23] and bio-materials [24]. On choosing the right materials for the low-cost microfluidic device, the following aspects need to be taken into consideration: the general physical properties, material cost, applications, surface wettability requirement, biocompatibility and chemical resistance.…”

Section: Materials For Low-cost Microfluidicsmentioning

confidence: 99%

Low‐cost microfluidics: materials and methods

Fan

2018

Micro & Nano Letters

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Microfluidics has been widely used in the biological, chemical and recently in the energy field. In the past decade, microfluidics has experienced tremendous growth in academia; researchers in various fields have been using microfluidics as a powerful tool for the enchantments of their research. However, the fabrication technologies of microfluidics are sourced from microelectromechanical systems and integrated circuit industry, which the fabrication process is costly and time-consuming, with the need of highly sophisticated instruments and experienced technical personnel to conduct fabrication process in the cleanroom environment. To lower the technical barriers for microfluidics, more and more researchers in different fields have invented various low-cost fabrication methods for microfluidics using polymers or paper materials. Comparing to the conventional microfabrication process conducted in the cleanroom, the low-cost fabrication methods are more flexible, with significant reduction in material cost, fabrication cost and processing time. This review is trying to introduce the most recent developments in low-cost microfluidics, from the aspects of materials, microfabrication and bonding technologies. The comparison and scope of application for different low-cost fabrication technologies for microfluidics were also provided in this review.

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“…Rigid silicon microelectrode devices with fused capillary catheters or integrated microfluidic channels have demonstrated combined intracortical recording and local drug release during intraoperative studies [ 37 , 38 , 39 , 40 ]. To better match the mechanical properties of the brain, microfluidic neural probes have been fabricated using many different polymers, including parylene, SU-8, and polydimethylsiloxane (PDMS) [ 41 , 42 , 43 , 44 , 45 ]. Despite an abundance of microfluidic neural probe materials and architectures, there are very few reports of such probes being used for drug delivery studies beyond intraoperative experiments at acute time points.…”

Section: Introductionmentioning

confidence: 99%

Fabrication Methods and Chronic In Vivo Validation of Mechanically Adaptive Microfluidic Intracortical Devices

Kim,

Mueller,

Schwartzman

et al. 2023

Micromachines

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Intracortical neural probes are both a powerful tool in basic neuroscience studies of brain function and a critical component of brain computer interfaces (BCIs) designed to restore function to paralyzed patients. Intracortical neural probes can be used both to detect neural activity at single unit resolution and to stimulate small populations of neurons with high resolution. Unfortunately, intracortical neural probes tend to fail at chronic timepoints in large part due to the neuroinflammatory response that follows implantation and persistent dwelling in the cortex. Many promising approaches are under development to circumvent the inflammatory response, including the development of less inflammatory materials/device designs and the delivery of antioxidant or anti-inflammatory therapies. Here, we report on our recent efforts to integrate the neuroprotective effects of both a dynamically softening polymer substrate designed to minimize tissue strain and localized drug delivery at the intracortical neural probe/tissue interface through the incorporation of microfluidic channels within the probe. The fabrication process and device design were both optimized with respect to the resulting device mechanical properties, stability, and microfluidic functionality. The optimized devices were successfully able to deliver an antioxidant solution throughout a six-week in vivo rat study. Histological data indicated that a multi-outlet design was most effective at reducing markers of inflammation. The ability to reduce inflammation through a combined approach of drug delivery and soft materials as a platform technology allows future studies to explore additional therapeutics to further enhance intracortical neural probes performance and longevity for clinical applications.

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SU-8 free-standing microfluidic probes

Cited by 12 publications

References 42 publications

Polymeric and Paper-Based Lab-on-a-Chip Devices in Food Safety: A Review

Polymeric and Paper-Based Lab-on-a-Chip Devices in Food Safety: A Review

Low‐cost microfluidics: materials and methods

Fabrication Methods and Chronic In Vivo Validation of Mechanically Adaptive Microfluidic Intracortical Devices

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