SU-8 based microprobes for simultaneous neural depth recording and drug delivery in the brain

Altuna, Ane; Bellistri, Elisa; Cid, Elena; Aivar, Paloma; Gal, Beatriz; Berganzo, J.; Gabriel, Gemma; Guimerà‐Brunet, Anton; Villa, Rosa; Fernández, Luís; Prida, Liset Menéndez de la

doi:10.1039/c3lc41364k

Cited by 114 publications

(101 citation statements)

References 49 publications

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“…And then using the electrochemical workstation called CHI660E to test the cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) [11]. Finally using the microelectrode arrays to determine signals of the neonatal dorsal root ganglion (DRG) explants.…”

Section: Discussionmentioning

confidence: 99%

A Flexible Microelectrode Array for Recording Signals of Culturing DRG Explants

Guan¹,

Chen²,

Li³

et al. 2016

dtetr

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Abstract. Owning to the advanced technology of microelectromechanical systems (MEMS), more and more precise microelectrode arrays are used to serve as neural prosthesis. Peripheral nerve injury and amputation have plagued neurosurgeons and patients. Neural interface have been served as a bridge between peripheral nerves and prosthetic limbs. In this study, to characterize the signals of culturing dorsal root ganglion (DRG) explants, a flexible electronic microelectrode arrays using SU-8 was designed to serve as neural interface to record neural signals of culturing DRG explants. The arrays are composed of thin gold electrode on a flexible material called SU-8, The materials and methods will play an important role in recording neural signals of culturing DRG explants. The goal of this study is to design an artificial limb that the amputees could control as if it was a natural extension of their own body.

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Section: Discussionmentioning

confidence: 99%

A Flexible Microelectrode Array for Recording Signals of Culturing DRG Explants

Guan¹,

Chen²,

Li³

et al. 2016

dtetr

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“…The third design added complexity due to its eight electric and fluidic ports in such a reduced device ( Figure 2C). With this prototype we recorded for the first time neural ensemble activity in response to local drug delivery at a microscale resolution (Altuna et al, 2013).…”

Section: Development Of Packaging Toolsmentioning

confidence: 99%

“…Over the last years, it has been demonstrated that SU-8 polymer provides optimal properties for neural applications (Lu et al, 2006;Cho et al, 2008;Fernández et al, 2009;Altuna et al, 2010Altuna et al, , 2012Altuna et al, , 2013. Its high-aspect ratio capability has enabled good dimensional control, and therefore, probes with vertical sidewalls provided a clean insertion into the soft tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Now, even lower temperature combined with higher pressure has been used to avoid internal forces and to guarantee probe planarity. In all cases, the mechanical suitability of SU-8-based probes were experimentally tested for neural application (Lu et al, 2006;Cho et al, 2008;Fernández et al, 2009;Altuna et al, 2010Altuna et al, , 2012Altuna et al, , 2013. In addition, new achievements regarding probe packaging are addressed in this document.…”

Section: Introductionmentioning

confidence: 99%

“…When electric and fluidic functions are integrated into a single microdevice, all connections have to fit into tight space restriction. Accordingly, our microfluidic SU-8 probes have been displayed every time by a dedicated packaging based on high-resolution 3D printing techniques (Fernández et al, 2009;Altuna et al, 2010Altuna et al, , 2012Altuna et al, , 2013.…”

Section: Introductionmentioning

confidence: 99%

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Polymer SU-8-Based Microprobes for Neural Recording and Drug Delivery

2015

Self Cite

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Citation:Altuna A, Berganzo J and Fernández LJ (2015) Polymer This manuscript makes a reflection about SU-8-based microprobes for neural activity recording and drug delivery. By taking advantage of improvements in microfabrication technologies and using polymer SU-8 as the only structural material, we developed several microprobe prototypes aimed to (a) minimize injury in neural tissue, (b) obtain high-quality electrical signals, and (c) deliver drugs at a micrometer precision scale. Dedicated packaging tools have been developed in parallel to fulfill requirements concerning electric and fluidic connections, size and handling. After these advances have been experimentally proven in brain using in vivo preparation, the technological concepts developed during consecutive prototypes are discussed in-depth now.

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Multifunctional Neural Interfaces for Closed‐Loop Control of Neural Activity

Chapman

Goshi

Şeker

2017

Adv Funct Materials

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Microfabrication and nanotechnology have significantly expanded the technological capabilities for monitoring and modulating neural activity with the goal of studying the nervous system and managing neurological disorders. This feature article initially provides a tutoriallike review of the prominent technologies for enabling this two-way communication with the nervous system via electrical, chemical, and optical means. Following this overview, the article discusses emerging high-throughput methods for identifying device attributes that enhance the functionality of interfaces. The discussion then extends into opportunities and challenges in integrating different device functions within a small footprint with the goal of closed-loop control of neural activity with high spatiotemporal resolution and reduced adverse tissue response. The article concludes with an outline of future directions in the development and applications of multifunctional neural interfaces.

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SU-8 based microprobes for simultaneous neural depth recording and drug delivery in the brain

Cited by 114 publications

References 49 publications

A Flexible Microelectrode Array for Recording Signals of Culturing DRG Explants

A Flexible Microelectrode Array for Recording Signals of Culturing DRG Explants

Polymer SU-8-Based Microprobes for Neural Recording and Drug Delivery

Multifunctional Neural Interfaces for Closed‐Loop Control of Neural Activity

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