Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model

Parayath, Neha N.; Nehoff, Hayley; Norton, Samuel E; Highton, Andrew J.; Taurin, Sébastien; Kemp, Roslyn A.; Greish, Khaled

doi:10.2147/ijn.s110251

Cited by 12 publications

(2 citation statements)

References 45 publications

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“…Therefore, the SMA-PTX micelle nanoformulation will offer an efficacious and nontoxic oral drug delivery. SMA-PTX micelle nanoformulation led to improved anticancer activity against colorectal cancer when compared with PTX [ 108 ] ( Figure 3 ).…”

Section: Toxicity and Safety Aspectsmentioning

confidence: 99%

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

Sharifi‐Rad

Quispe

Patra

et al. 2021

Oxidative Medicine and Cellular Longevity

135

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Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and breast cancers. The application of this compound is difficult because of limited solubility, recrystalization upon dilution, and cosolvent-induced toxicity. In these cases, nanotechnology and nanoparticles provide certain advantages such as increased drug half-life, lowered toxicity, and specific and selective delivery over free drugs. Nanodrugs possess the capability to buildup in the tissue which might be linked to enhanced permeability and retention as well as enhanced antitumour influence possessing minimal toxicity in normal tissues. This article presents information about paclitaxel, its chemical structure, formulations, mechanism of action, and toxicity. Attention is drawn on nanotechnology, the usefulness of nanoparticles containing paclitaxel, its opportunities, and also future perspective. This review article is aimed at summarizing the current state of continuous pharmaceutical development and employment of nanotechnology in the enhancement of the pharmacokinetic and pharmacodynamic features of paclitaxel as a chemotherapeutic agent.

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Section: Toxicity and Safety Aspectsmentioning

confidence: 99%

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

Sharifi‐Rad

Quispe

Patra

et al. 2021

Oxidative Medicine and Cellular Longevity

135

View full text Add to dashboard Cite

show abstract

“…Paclitaxel (PTX) is an effective drug used for the treatment of cancer, which is extensively applied to clinical therapeutic treatment of NSCLC 8,9. However, PTX also exhibits severe side effects including vomiting, diarrhea and myelosuppression 8,10. In recent years, drug combination is an effective method to reduce cell toxicity and improve the efficacy of therapy 11.…”

Section: Introductionmentioning

confidence: 99%

<p>Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo</p>

Chen¹,

Zhang²,

Zhang³

2019

DDDT

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Background: Non-small-cell lung cancer (NSCLC) was known as the most malignant tumor. Paclitaxel (PTX) is the effective drug used for the treatment of NSCLC; however, it also exhibits severe side effects. Emodin could induce apoptosis of NSCLC cells and serve as a potential cancer therapeutic agent. However, the effects of combination of emodin with PTX on NSCLC remain unclear. Thus, this study aimed to investigate the effects of emodin in combination with PTX on A549 cells. Materials and methods: The effects of combination treatment on the proliferation, apoptosis and invasion of NSCLC cells were evaluated by CCK-8, flow cytometric and TUNEL assays, respectively. In addition, Western blotting was used to detect the expressions of Bax, Bcl-2, active caspase 3, p-Akt and ERK in cells. Results: Combination of emodin with PTX synergistically inhibited the proliferation of A549 cells in vitro. In addition, we found that emodin significantly enhanced PTX-induced apoptosis in A549 cells via increasing the expressions of Bax and active caspase 3 and decreasing the levels of Bcl-2, p-Akt and p-ERK. Moreover, emodin markedly enhanced antitumor effect of PTX on A549 xenograft without significant side effects in vivo. Conclusion: Our findings indicated that emodin could significantly enhance antitumor effect of PTX in vitro and in vivo. Therefore, the combination of emodin with PTX may serve as a potential strategy for the treatment of patients with NSCLC.

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Oral Delivery of Multicompartment Nanomedicines for Colorectal Cancer Therapeutics: Combining Loco‐Regional Delivery with Cell‐Target Specificity

Akhter

Simpson

Fletcher

et al. 2019

Advanced Therapeutics

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Nanomaterials for targeted delivery of chemotherapeutics have received significant attention owing to their potential to enhance the accumulation of therapeutics in diseased tissue. However, in diseases with poor vascularization, such as colorectal cancer (CRC), intravenously injected materials have reduced access to the site of interest. To overcome this challenge, oral administration of targeted nanomedicines is highly desirable. Here, a multicomponent drug delivery system incorporating a degradable alginate microcapsule, formulated to encapsulate micelles targeted to the CD44 receptor is presented. Functional micelles are generated by coupling hyaluronic acid (to target CD44 receptor) to block copolymers of poly(ethylene glycol) monomethyl ether methacrylate and poly(methyl methacrylate). When encapsulated into alginate microcapsules, these micelles form the basis of a novel oral delivery system that offers protection from degradative compartments of the gastrointestinal tract (GIT) and regio‐specific release. The microcapsules demonstrate desirable site‐specific degradation properties in an orthotopic CRC xenograft mouse model, yielding enhanced accumulation of micelles within CD44+ colorectal tumors. The results illustrate that such materials successfully navigate the GIT, regio‐specifically release targeted micelles at the tumor site, and consequently accomplish enhanced accumulation within tumor tissue. Such multi‐component nanomaterials offer a promising means for addressing challenges in treating CRC and difficult to treat diseases.

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Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model

Cited by 12 publications

References 45 publications

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

<p>Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo</p>

Oral Delivery of Multicompartment Nanomedicines for Colorectal Cancer Therapeutics: Combining Loco‐Regional Delivery with Cell‐Target Specificity

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