Abstract:To evaluate the effects of styrene exposure on learning, adult male Long-Evans rats learned repeated reversals of a spatial discrimination task. Styrene monomer (50% voYvol in corn oil) was administered by gavage to groups of eight rats at 500 mg/kg/day, 5 daydweek, for 8 weeks in Experiments (Exps) I and I1 (total dose = 20.0 g/kg) or for 1,3,5, or 8 weeks in Exp I11 (total dose = 2.5, 7.5, 12.5, or 20.0 g/kg). Control rats received corn oil vehicle for 8 weeks. Reversal training began 8 (Exp I), 10 (Exp 11).… Show more
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