Stunting is a recognized problem: Evidence for the potential benefits of ω-3 long-chain polyunsaturated fatty acids

Rahmawaty, Setyaningrum; Meyer, Barbara J.

doi:10.1016/j.nut.2019.110564

Cited by 22 publications

(17 citation statements)

References 136 publications

(134 reference statements)

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“…These results directly confirm previously reported observations of positive association between n-3 FA and growth among children of <5 years old from Malawi (46) . Patterns in our data affirm conclusion of recent systematic review that supplementation efforts to prevent stunting might be most effective by focusing on dietary enrichment for EPA and DHA, especially in children less than 2 years old (47,48) . Very few supplementation studies of n-3 has been done among children older than 2 years, and meta-analysis of available data did not find significant benefit for growth in older children (48) .…”

Section: Baseline Essential Fatty Acid Deficiency Predicts Worse Growthsupporting

confidence: 89%

“…Of note, although n-3 was not associated with growth among CHEU and CPHIV, the fact that higher total PUFA (a composite which includes n-3 FA) is associated with higher attained stature in all children suggests that indeed DHA þ EPA supplementation could potentially benefit growth for all children in this setting. Data from this study suggest that CHUU who are less medically complex may derive marginally higher benefit from such intervention compared to CHEU and CPHIV (47,48) . We found that low oleic acid and low total MUFA predicted better growth over 12 months.…”

Section: Baseline Essential Fatty Acid Deficiency Predicts Worse Growthmentioning

confidence: 78%

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Association of serum PUFA and linear growth over 12 months among 6–10 years old Ugandan children with or without HIV

Pobee

Fenton

Sikorskii

et al. 2022

Public Health Nutr.

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Objective: To quantify PUFA-associated improvement in linear growth among children aged 6–10 years. Design: Serum fatty acids (FA), including essential FA (EFA) (linoleic acid (LA) and α-linolenic acid (ALA)) were quantified at baseline using GC-MS technology. FA totals by class (n-3, n-6, n-9, PUFA and SFA) and FA ratios were calculated. Height-for-age Z-score (HAZ) relative to WHO population reference values were calculated longitudinally at baseline, 6 and 12 months. Linear regression models estimated PUFA, HIV status and their interaction-associated standardised mean difference (SMD) and 95 % CI in HAZ over 12 months. Setting: Community controls and children connected to community health centre in Kampala, Uganda, were enrolled. Participants: Children perinatally HIV-infected (CPHIV, n 82), or HIV-exposed but uninfected (CHEU, n 76) and community controls (n 78). Results: Relative to highest FA levels, low SFA (SMD = 0·31, 95 % CI: 0·03, 0·60), low Mead acid (SMD = 0·38, 95 % CI: 0·02, 0·74), low total n-9 (SMD = 0·44, 95 % CI: 0·08, 0·80) and low triene-to-tetraene ratio (SMD = 0·42, 95 % CI: 0·07, 0·77) predicted superior growth over 12 months. Conversely, low LA (SMD = -0·47, 95 % CI: −0·82, −0·12) and low total PUFA (sum of total n-3, total n-6 and Mead acid) (SMD = -0·33 to −0·39, 95 % CI: −0·71, −0·01) predicted growth deficit over 12 months follow-up, regardless of HIV status. Conclusion: Low n-3 FA (ALA, EPA and n-3 index) predicted growth deficits among community controls. EFA sufficiency may improve stature in school-aged children regardless of HIV status. Evaluating efficacy of diets low in total SFA, sufficient in EFA and enriched in n-3 FA for improving child growth is warranted.

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Section: Baseline Essential Fatty Acid Deficiency Predicts Worse Growthsupporting

confidence: 89%

Section: Baseline Essential Fatty Acid Deficiency Predicts Worse Growthmentioning

confidence: 78%

Association of serum PUFA and linear growth over 12 months among 6–10 years old Ugandan children with or without HIV

Pobee

Fenton

Sikorskii

et al. 2022

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…A validated self-administrative questionnaire was used to collect the data. The questionnaire divided into 4 sections: socioeconomic characteristics (educational background and occupation of mother); health benefits of fish-related knowledge [ 8 9 14 15 16 17 ] (consisted of 22 closed-questions with dichotomous answers, yes/no); fish processing technique-related knowledge [ 14 18 19 20 21 ] (consisted of 20 questions with dichotomous answers, yes/no); and organoleptic properties of fish-related attitude (consisted of 30 questions based preliminary study [ 14 22 23 24 ] and interview to 50 participants [unpublished data] with 5-Likert scale: strongly disagree, disagree, neutral, agree, strongly agree) ( Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…The accretion of DHA in the brain continues up to 2 yrs of age and progressively rises in the cerebral cortex until 18 yrs of age [ 5 6 ], even in life span [ 7 ]. Hence, sufficient intake of n-3 LCPUFA is fundamental, not only during the growth spurt period, but also across the age to maintain optimal health [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A mothers' perspective on fish and her child's fish consumption in Surakarta, Indonesia

et al. 2021

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“…In Indonesia, the majority of children have PUFA consumption levels that are below than the Food and Agriculture Organization (FAO) and World Health Organization (WHO) recommended dietary limits, particularly for ALA. Indonesian children consume only 40% of the recommended intake level of ALA and 67% of the total essential fatty acids that are recommended by FAO/WHO [27]. The nutrient deficiencies of ALA (Omega-3) and LA (Omega-6) may cause stunting and obesity [28][29][30][31]. The nutrient deficiencies in ALA (Omega-3) and LA (Omega-6) might be tackled by developing Sacha Inchi plants in Indonesia to fulfill the requirements for essential fatty acids of Indonesian children.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Cultivation Conditions on Sacha Inchi (Plukenetia volubilis L.) Seed Production and Oil Quality (Omega 3, 6, 9)

et al. 2022

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Sacha Inchi (Plukenetia volubilis Linneo, Euphorbiaceae) is known as a Peruvian seed containing a high level of unsaturated fatty acids, such as α-linolenic acid (Omega-3), linoleic acid (Omega-6), and oleic acid (Omega-9). These essential fatty acids are important functional foods due to their benefits for human health. Considering its benefits, it is necessary to find the right cultivation conditions to develop Sacha Inchi in Indonesia, where it has not been widely cultivated. This study aimed to determine the adaptability of Sacha Inchi to different cultivation conditions and the effects of these conditions on seed production and oil quality. Sacha Inchi plants were cultivated under three different cultivation conditions (open area, mixed cultures, and agroforestry) and the seeds were harvested monthly to determine the seed production and oil quality. The results showed that seed production in the open area was higher than in other conditions. The highest oil yield from monthly harvesting was found in mixed cultures. Interestingly, the level of Omega-3 content in the agroforestry condition was higher compared to other conditions. The level of Omega-6 and Omega-9 content in the open area was higher than in mixed cultures and agroforestry. However, the content of unsaturated fatty acids in the three different cultivation conditions was not significantly different, being 91.88% in the open area, 92.53% in mixed cultures, and 92.97% for agroforestry. In conclusion, the cultivation of Sacha Inchi under open areas is recommended due to its seed productivity which will affect the total oil production.

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Stunting is a recognized problem: Evidence for the potential benefits of ω-3 long-chain polyunsaturated fatty acids

Cited by 22 publications

References 136 publications

Association of serum PUFA and linear growth over 12 months among 6–10 years old Ugandan children with or without HIV

Association of serum PUFA and linear growth over 12 months among 6–10 years old Ugandan children with or without HIV

A mothers' perspective on fish and her child's fish consumption in Surakarta, Indonesia

The Effect of Cultivation Conditions on Sacha Inchi (Plukenetia volubilis L.) Seed Production and Oil Quality (Omega 3, 6, 9)

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