Studying the role of interlocus interactions of folate cycle genes and matrix metalloproteinases in the formation of fetal growth retardation

Efremova, Olesya

doi:10.18413/2658-6533-2022-8-1-0-3

Cited by 2 publications

(1 citation statement)

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“…A clinical examination of all pregnant women was conducted by an experienced obstetrician at the perinatal center of the St. Joasaph Belgorod Regional Clinical Hospital. Inclusion criteria were the following: singleton pregnancy, 37-40 gestation weeks [23,30], and born in Central Russia and self-reported Russian origin [31]; exclusion criteria were the following: pregnant with pathological placental location, uterine leiomyoma, malformation disease of female reproductive organs, hepatic/renal failure, diabetes mellitus, and isosensitization of blood group systems (ABO/Rh factor) [32,33]. Written informed consent was obtained from all participating individuals, and the present study was approved by the Local Ethical Committee of the Belgorod State University.…”

Section: Study Subjectsmentioning

confidence: 99%

Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia

Abramova

Churnosova

Efremova

et al. 2022

Life

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The aim of this study was to explore the effects of pre-pregnancy overweight/obesity on the pattern of association of hypertension susceptibility genes with preeclampsia (PE). Ten single-nucleotide polymorphisms (SNPs) of the 10 genome-wide association studies (GWAS)-significant hypertension/blood pressure (BP) candidate genes were genotyped in 950 pregnant women divided into two cohorts according to their pre-pregnancy body mass index (preBMI): preBMI ≥ 25 (162 with PE and 159 control) and preBMI < 25 (290 with PE and 339 control). The PLINK software package was utilized to study the association (analyzed four genetic models using logistic regression). The functionality of PE-correlated loci was analyzed by performing an in silico database analysis. Two SNP hypertension/BP genes, rs805303 BAG6 (OR: 0.36–0.66) and rs167479 RGL3 (OR: 1.86), in subjects with preBMI ≥ 25 were associated with PE. No association between the studied SNPs and PE in the preBMI < 25 group was determined. Further analysis showed that two PE-associated SNPs are functional (have weighty eQTL, sQTL, regulatory, and missense values) and could be potentially implicated in PE development. In conclusion, this study was the first to discover the modifying influence of overweight/obesity on the pattern of association of GWAS-significant hypertension/BP susceptibility genes with PE: these genes are linked with PE in preBMI ≥ 25 pregnant women and are not PE-involved in the preBMI < 25 group.

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