Studying the Kinetics of n-Butyl-Cyanoacrylate Tissue Adhesive and Its Oily Mixtures

Use of confocal Raman microscopy to characterise ethyl cyanoacrylate adhesive depth curing

“…Significant progress towards adhesive performance improvement can be realized through the development of a suitable spatial temporal method capable of studying localised curing behaviour or conversion at different spatial locations within the bondline. Over recent years, several optical spectroscopy techniques such as FTIR and Raman spectroscopy have been widely applied as powerful non-destructive methods to follow dynamic polymerisation reactions [4][5][6] . This paper presents Confocal Raman Microscopy (CRM) as a simple, efficient and accurate method for this type of investigation.…”

“…Edwards et al have employed Raman spectroscopy to study curing of a cyanoacrylate system for the forensic enhancement of latent fingerprints 17 18 . Recently Nedvedova et al analysed various polymerised N-butyl-2-cyanoacrylate-Lipiodol mixtures by Raman spectra mapping of the CA polymer x-y direction 4 , however cyanoacylate compositional changes along the z-axis was not explored. When considering the range of applications that are used in industry for the determination of cyanoacrylate chemical heterogeneity 19,5 , it is perhaps surprising that little work has gone into utilising Confocal Raman spectroscopy to probe interfacial and diffusional aspects of bondline polymerisations and the study of spatially resolved polymerisation/curing rates.…”

Raman Spectroscopic Characterization of Polymerization Kinetics of Cyanoacrylate Embolic Glues for Vascular Embolization

“…During the injection and occlusion processes, the polymerization kinetics play an essential role in the control of droplet structure and subsequent distribution [ 9 , 10 , 11 ]. High glue concentration mixtures (e.g., pure glue or 75%) tend to occlude towards high-flow vessels and proximal arteries, while low concentration mixtures (e.g., 25%) permeate further for the occlusion of distal niduses and small low-flow vessels [ 12 , 13 , 14 ]. Yet glue mixtures of high concentrations (e.g., 50%) can cause the adhesion of the microcatheter to the blood vessels [ 15 , 16 ].…”

“…Numerous studies have employed Raman spectroscopy to study curing of cyanoacrylate-fumed fingerprints and the kinetics of cyanoacrylate-based adhesives, as well as their dependences on substrate types, temperature and film thickness [ 25 , 26 , 27 , 28 , 29 , 30 ]. Recently, Nedvedova et al [ 12 ] analyzed the kinetics of n-Butyl-cyanoacrylate adhesives and its oily mixtures using Raman spectroscopy by contacting drops of two reaction solutions. The polymerization creation method allows for the characterization of polymerization of a thin film, which cannot reflect the volumetric polymerization of glue–oil mixtures.…”

Comparison of 2-Octyl Cyanoacrylate Topical Skin Adhesive and Simple Interrupted Nylon Sutures for Wound Closure in Ankle Fracture Surgery

“…It adheres to the skin and itself, forming a clean strong adherent bond that holds the edges of skin wounds together so that wounds can heal normally underneath the film. 3,6,10,23 Based on this mechanism, the clinical application of 2-octyl cyanoacrylate in wound closure has shown similar effectiveness and safety compared to suturing. 13,24,29 In orthopedic surgery, interest in the use of topical skin adhesives has been increasing, and many studies on topical skin adhesives have been performed in the field of joint arthroplasty surgery.…”