Studying the Influence of Epinephrine Mixed With Prednisolone on The Neurologic Side Effects After Recovery in Patients Suffering From Cardiopulmonary Arrest

Clinical benefits of corticosteroid administration during adult cardiopulmonary resuscitation: A systemic review and meta-analysis

“…A total of six articles, published between 1984 and 2016, were included for data extraction and meta-analysis. Four were RCTs[ 7 , 9 , 10 , 17 ], one was prospective non-RCT[ 11 ], and the other was a retrospective study[ 18 ]. The studies were conducted in Asia ( n = 3), Europe ( n = 2), and North America ( n = 1).…”

“…The studies were conducted in Asia ( n = 3), Europe ( n = 2), and North America ( n = 1). Three studies included patients with OHCA[ 10 , 11 , 17 ] and three included patients with in-hospital cardiac arrest[ 7 , 9 , 18 ]. Two trials evaluated the clinical benefits of co-intervention with corticosteroid, vasopressin, or epinephrine protocols[ 7 , 9 ].…”

“…Two trials evaluated the clinical benefits of co-intervention with corticosteroid, vasopressin, or epinephrine protocols[ 7 , 9 ]. Four trials directly investigated the efficacy of steroids alone, including methylprednisolone[ 17 ], dexamethasone[ 10 ], hydrocortisone[ 11 ], and other steroids[ 18 ]. More than three-fourths of the cardiac arrests were witnessed.…”

“…Overall survival rate at hospital discharge: All six studies reported the association between steroid use and the survival rate at hospital discharge[ 7 , 9 - 11 , 17 , 18 ]. Four of the six were RCTs and two were non-RCTs.…”

“…Rate of sustained ROSC: Four studies examined the association between steroid use and the rate of sustained ROSC[ 7 , 9 , 11 , 17 ]. The pooled data was homogeneous ( I 2 = 0%, P < 0.001).…”