Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by in vivo confocal Raman spectroscopy

Mélot, Mickaël; Pudney, Paul D. A.; Williamson, Ann-Marie; Pol, A. van der; Puppels, Gerwin J.

doi:10.1016/j.jconrel.2009.04.023

Cited by 118 publications

(94 citation statements)

References 43 publications

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“…Derivative data from drug permeation study of P-SN and P-SN-OA gels and solutions using untreated skin or skin treated by microwave as the permeation barrier. bent cis configuration, oleic acid has been reported to be able to disturb the highly ordered intercellular lipid packing of predominantly hydrophobic saturated chains [45][46][47][48]. It could extract a fraction of endogenous lipid and form separate phases within the intercellular lipid lamellae [45,[48][49][50].…”

Section: Mechanisms Of Drug Permeationmentioning

confidence: 99%

“…bent cis configuration, oleic acid has been reported to be able to disturb the highly ordered intercellular lipid packing of predominantly hydrophobic saturated chains [45][46][47][48]. It could extract a fraction of endogenous lipid and form separate phases within the intercellular lipid lamellae [45,[48][49][50]. This accounted for the formation of an extensive number of sub-domain divisions which were readily rigidified by freely soluble pectin from gel to form a large drug-impermeable area that led to low drug permeation.…”

Section: Mechanisms Of Drug Permeationmentioning

confidence: 99%

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Microwave: Effects and Implications in Transdermal Drug Delivery

Anuar¹,

Wong²

2013

PIER

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Abstract-This study investigated transdermal drug delivery mechanisms of pectin and pectin-oleic acid (OA) gels and their effects on skin barrier treated by microwave. Hydrophilic pectin-sulphanilamide gels, with or without OA penetration enhancer, were subjected to drug release and skin permeation studies. The skins were untreated or microwave-treated, and characterized by infrared spectroscopy, raman spectroscopy, thermal, electron microscopy and histology techniques. Unlike solid film, skin treatment by microwave at 2450 MHz demoted drug permeation especially from OA-rich pectin gel. The pectin-skin binding was facilitated by gel with freely soluble pectin molecules instead of solid film with entangled chains. It was promoted when microwave fluidized stratum corneum into structureless domains, or OA extracted endogenous lipid fraction and formed separate phases within intercellular lipid lamellae. This led to a remarkable decrease in transdermal drug permeation. Microwave-enhanced transdermal delivery must not be implemented with pectin gel. In skin treated by microwave, the penetration enhancer in gel can act as a permeation retardant.

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Section: Mechanisms Of Drug Permeationmentioning

confidence: 99%

Section: Mechanisms Of Drug Permeationmentioning

confidence: 99%

Microwave: Effects and Implications in Transdermal Drug Delivery

Anuar¹,

Wong²

2013

PIER

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“…Retinol (Mélot et al, 2009); Morphine (Monti et al, 2001); Arginine vasopressin (Nair&Pachangula, 2003); Insulin (Pillai & Pachangula, 2003); Enoxacin (Fang et al, 1998). Table 2.…”

Section: Terpenesmentioning

confidence: 99%

Chemical and Physical Enhancers for Transdermal Drug Delivery

Escobar-Chávez¹,

Rodríguez-Cruz²,

Domínguez-Delgado³

2012

Pharmacology

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“…Skin is the most accessible organ and therefore should be a strategic target. In addition to diagnostic applications, 10 spectroscopy could provide significant guidance for monitoring and optimising transdermal drug delivery, 11 as well as understanding dermal toxicity from external agents such as nanoparticles, chemicals and radiation. 12 The question should therefore be posed: in terms of in-vivo clinical applications, is the vision right?…”

Section: Introductionmentioning

confidence: 99%

Spectropathology for the next generation: Quo vadis?

Byrne

Barańska

Puppels

et al. 2015

Analyst

Self Cite

110

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Although the potential of vibrational spectroscopy for biomedical applications has been well demonstrated, translation into clinical practice has been relatively slow. This Editorial assesses the challenges facing the field and the potential way forward. While many technological challenges have been addressed to date, considerable effort is still required to gain acceptance of the techniques among the medical community, standardise protocols, extend to a clinically relevant scale, and ultimately assess the health economics underlying clinical deployment. National and international research networks can contribute much to technology development and standardisation. Ultimately, large-scale funding is required to engage in clinical trials and instrument development.

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Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by in vivo confocal Raman spectroscopy

Cited by 118 publications

References 43 publications

Microwave: Effects and Implications in Transdermal Drug Delivery

Microwave: Effects and Implications in Transdermal Drug Delivery

Chemical and Physical Enhancers for Transdermal Drug Delivery

Spectropathology for the next generation: Quo vadis?

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