The use of nanofluids and surface enhancers today are among the new technologies used to increase heat transfer. In this study, heat transfer phenomena in heat exchanger were investigated using Al2O3 nanoparticles and modified spiral band as flow turbulator. Results are verified with well‐known correlations. The results show that the tube with cross‐hollow twisted tape inserts has the best exergetic performance for different hollow widths of the tape. Clearance, which is defined as the width between the tube and twisted tape, also affects the heat transfer performance. The smaller the clearance, the better is the exergetic performance. The tube can achieve the best exergetic performance when the number of unilateral twisted tapes is four. The results showed that increasing nanofluid concentration improves exergetic performance.