Studying the Effect of Flavonoids Extracted from Haloxylon salicornium and Zygophilium coccinium Plants on Burn Healing in Diabetic White Rabbits

Abstract

Background: The use of plant extracts is a successful way to treat many diseases. Desert plants are rich in many antioxidant compounds, so they have been used since ancient times in folk medicine. The most important of these compounds are flavonoids that contain in their composition an aromatic ring and an oxidative hydroxyl group, which resists the free radical compounds formed in affected tissue and neutralize the tissue to reach the state of recovery.Objectives: The study aims to find an effective treatment to prevent tissue damage in burns or wounds in diabetic patients. Materials and methods: Two plants were used in this study; Haloxylon salicornicum and Zygophyllum coccineum (after proving their antioxidant activity by DPPH assay, with different concentrations for both plants). Flavonoids were extracted from them, and they were used to treat burns in laboratory rabbits with diabetes. The incidence of infection was confirmed by histological and hematological studies. Then, we studied of the effect of using the treatment on some blood variables, hormones and antioxidants during the treatment period for the stability of their effectiveness for treatment. Results:The study proved the effectiveness of these compounds by accelerating the treatment period despite diabetes and getting fast and effective results. Conclusion: Flavonoids of H. coccineum and Z. coccineum proved a high effectiveness of treatment compared to chemotherapy and accelerated the healing period of the wound.