Studying the Effect of Different Gelling Agent on the Preparation and Characterization of Metronidazole as Topical Emulgel

Daood, Noor M; Jassim, Zainab E.; Gareeb, Mowafaq M; Zeki, Hiba

doi:10.22159/ajpcr.2019.v12i3.31504

Cited by 28 publications

(20 citation statements)

References 5 publications

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“…The spreadability of gel before cycling test showed that the higher the concentration of the gelling agent, the smaller the spread area of the gel preparation. Increasing the concentration of gelling agent causes the gel to become thicker so that its spreading power decreases (Daood et al, 2019). Spreadability evaluation showed that spreadability value of formula are varied, range of 9 -29 mm 2 for carbopol based gel, and 7 -31 mm 2 for HPMC based gel.…”

Section: Resultsmentioning

confidence: 99%

Study of Wound Healing Activity and Skin Irritation of Chili Leaves (Capsicum frutescens L.) Gel in Rats (Rattus novergicus)

Lebang¹,

Siampa

Nurmiati

2021

JFG

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Chili pepper leaves have been used empirically as wound healing caused by sharp objects. Several studies show its antibacterial and wound healing activity. This study aims to make gel from chili leaves extract, then to determine its wound healing activity and its irritating properties on rat’s skin. Gel was made using variations type and concentration of gelling agent, consist of carbopol 0.5%, 0.75%, 1% and hydroxypropylmetlcellulose at 2.5%, 5% and 7.5% respectively. Cycling test then conducts to determined its physical stability. Gel that physically stable then evaluated its activity as a wound healer and skin irritation test. Results showed that all formula has no altered on organoleptic properties and pH value. Gel that made from 0.5% carbopol (F2) and 7.5% of HMPC (F5) has no change in spreadability and adhesion properties. Based on statistically analysis using paired t-test and one-way ANOVA, it concludes that F2 and F5 physically stable and could follow wound healer evaluation. Wound healer evaluation show that healing time (days) of carbopol base gel (F2) is 10.2±1.26, HPMC based gel is 8±0.82. Length of incision wound (cm) at the 8th day are 0.5±0.183 for F2 and 0.06±0.071 for F5. Statistically analysis of healing time (p<0.01) and wound length (p<0.05) show that F5 that contain 5% HPMC has significantly different compare to negative control. The results of the irritation test showed that gel formulas not caused erythema and edema on rat’s skin. It can be concluded that gel of chili pepper leave extract that made with 5% of HPMC has wound healing activity and safety to use.

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Section: Resultsmentioning

confidence: 99%

Study of Wound Healing Activity and Skin Irritation of Chili Leaves (Capsicum frutescens L.) Gel in Rats (Rattus novergicus)

Lebang¹,

Siampa

Nurmiati

2021

JFG

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“…The difference in gelling agents affects the release of medicinal substances in the preparation. Different gelling agents will have different release profiles [14], thus causing differences in the Inhibition of the preparation against microbes. It was also interesting to note that previous research indicated the interaction of Carbopol® and Polysorbate affecting its diffusional behavior [15].…”

Section: Antibacterial and Antifungal Activity Of Tto Preparationsmentioning

confidence: 99%

Factors Affecting Antibacterial and Antifungal Properties of Microemulsion Gel containing Tea Tree Oil

Nugraheni¹,

Chasanah²,

Maulana³

et al. 2021

Advances in Health Sciences Research

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Tea tree oil (Melaleuca alternifolia) has been acknowledged for its antibacterial and antifungal properties. Previous publications revealed that the tea tree oil has antibacterial activity against Propionibacterium acnes, which is the leading cause of acne, Staphylococcus aureus that caused various skin infections, and antifungal activity against Candida albicans. In this work, we aim to investigate the effect of microemulsion preparations in various gelling agents to their antibacterial and antifungal properties.Microemulsions have smaller droplets size than conventional emulsions; thus, we hypothesized that there would be a different effect on their inhibitory properties. The tea tree oil is formulated into a microemulsion and conventional emulsion, followed by incorporation into different gelling agents: Carbopol 940, Hydroxy-propyl methylcellulose, and sodium alginate. Physicochemical properties, such as pH, viscosity, and physical stability, had also been tested. The antibacterial and antifungal properties were tested using agar well diffusion methods. The microemulsion size was (26.23 + 0.15) nm, the pH of the final gel formulations was 4 to 7, and all formulations were physically stable under room temperature. The diameter of inhibition zones against bacteria and fungus was statistically analyzed using the multifactorial ANOVA method. The factors significantly affecting antibacterial and antifungal activities are the species of fungus and bacteria (p <0.001), gelling agents in formulations (p <0.05), and emulsions preparations (p <0.001). It was also interesting to note that these factors were significant on the activities tested (p <0.05).

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“…To overcome this limitation, emulgels were introduced. Furthermore, emulgels have the benefits of spreadability, adhesion, viscosity, and the highest drug release (Noor et al 2019).…”

Section: Emulgelsmentioning

confidence: 99%

Transdermal delivery systems in cosmetics

et al. 2020

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Transdermal delivery systems have been intensively studied over the past 2 decades, with the focus on overcoming the skin barrier for more effective application of pharmaceutical and cosmetic products. Although the cosmeceutical industry has made a substantial progress in the development and incorporation of new and effective actives in their products, the barrier function of the skin remains a limiting factor in the penetration and absorption of these actives. Enhancement via modification of the stratum corneum by hydration, acting of chemical enhancers on the structure of stratum corneum lipids, and partitioning and solubility effects are described. This review summarizes the advances in the development and mechanisms of action of chemical components that act as permeation enhancers, as well as the advances in appropriate vehicles, such as gels, emulsions, and vesicular delivery systems, that can be used for effective transdermal delivery.

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Studying the Effect of Different Gelling Agent on the Preparation and Characterization of Metronidazole as Topical Emulgel

Cited by 28 publications

References 5 publications

Study of Wound Healing Activity and Skin Irritation of Chili Leaves (Capsicum frutescens L.) Gel in Rats (Rattus novergicus)

Study of Wound Healing Activity and Skin Irritation of Chili Leaves (Capsicum frutescens L.) Gel in Rats (Rattus novergicus)

Factors Affecting Antibacterial and Antifungal Properties of Microemulsion Gel containing Tea Tree Oil

Transdermal delivery systems in cosmetics

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