Studying the effect of diabetes mellitus type 2 on prostate related parameters: A prospective single institutional study

Elabbady, Ahmed; Hashad, Mohamed M.; Kotb, Ahmed; Ghanem, Ali

doi:10.1016/s1569-9056(17)30468-2

Cited by 6 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the results were not statistically significant at 5% CI (p = 0.832). This finding differs with Ahmed Elabbady's study findings in which diabetes was significantly associated with lower serum PSA and testosterone, but larger PV [24]. We did not include the correlation with ethnicity and testosterone levels as an endpoint in our study, which could explain the findings in Elabbady's study.…”

Section: Discussioncontrasting

confidence: 88%

The correlation between obesity and prostate volume in patients with benign prostatic hyperplasia at Charlotte Maxeke Johannesburg Academic Hospital

2021

View full text Add to dashboard Cite

Background Benign prostatic hyperplasia (BPH) is on the increase placing a substantial burden on health care systems. Recent studies have shown that men with high body mass index (BMI) and central obesity, as denoted by waist circumference (WC) have bigger prostate volumes (PV) with subsequent increase in lower urinary tract symptoms (LUTS) than men with normal BMI. The purpose of this research was to investigate the correlation between Obesity and PV in patients with BPH. Methods The study included 178 men aged between 50 and 75 years with BPH seen at Charlotte Maxeke Johannesburg academic hospital (CMJAH) Urology Outpatient Department between September 2018 and February 2019. Weight and height measurements were obtained to calculate BMI. Furthermore, WC was measured using a measuring tape, while a transrectal ultrasound (TRUS) was used to measure PV. Patient demographics, clinical characteristics such as hypertension, diabetes, smoking and prostate specific antigen (PSA) were also noted. Results Patients in the study had a mean age of 64.87 ± 6.526 years and the mean BMI was 27.31 ± 3.933 kg/m2. The mean PV of each BMI group were 52.92 ± 38.49, 61.00 ± 33.10 and 64.86 ± 37.46 cm3 for normal, overweight and obese groups, respectively, and the average PV score was 59.36 ± 36.507 cm3. The mean PSA score was 4.30 ± 3.126 with a range of 1.3–6.4, while the mean WC was 98.67 cm. There was no correlation between BMI and PV (p value = 0.195) as well as between PV and WC, hypertension, diabetes or smoking. The results revealed that the relationship between PV with PSA level as well as age was significant (p value = 0.001, p value = 0.009, respectively). Conclusion The results showed no correlation between BMI and PV. Diabetes and hypertension as well had no positive correlation with PV. A follow-up study may be indicated to look at the correlation between obesity, LUTS and urinary flow rates to establish whether aggressive management of obesity would have significant impact on the management of BPH.

show abstract

Section: Discussioncontrasting

confidence: 88%

The correlation between obesity and prostate volume in patients with benign prostatic hyperplasia at Charlotte Maxeke Johannesburg Academic Hospital

2021

View full text Add to dashboard Cite

show abstract

“…34,43,50 PSA values that has been reported by many studies. [52][53][54][55] Our study is not devoid of limitations. The duration and dose of TRT of the RCTS in the analysis of the first strategy is very heterogeneous.…”

Section: Discussionmentioning

confidence: 97%

Association between prostate‐specific antigen and serum testosterone: A systematic review and meta‐analysis

et al. 2020

View full text Add to dashboard Cite

Background Serum testosterone assays are an important tool in the clinical evaluation of a number of endocrine disorders including male hypogonadism. However, serum testosterone has a limited role in real clinical use due to its inaccuracy. We aimed to assess the association between prostate‐specific antigen (PSA) and testosterone as well as the effects of various types of testosterone replacement therapy (TRT) for PSA level. Methods Two electronic databases were screened: PubMed (1966 through December 2018) and Cochrane Library (1993 through December 2018). The first strategy compared the overall increase in PSA following testosterone treatment compared with placebo. The second strategy analyzed the overall association between PSA and testosterone among the observational studies. Results In the first strategy, 22 articles were included in the final analysis. In the second strategy, 18 studies were included. Testosterone replacement therapy (TRT) showed a significant change in PSA level compared to that in the placebo group (mean difference [MD]: 0.13, 95% CI: 0.01‐0.25, P = .04). Compared to placebo, only intramuscular (IM) TRT shows a significant change in PSA level group (MD: 0.16, 95% CI: 0.01‐0.30, P = .04), as neither the oral nor topical type showed a significant change in PSA. In the second strategy analysis, there was no overall correlation found between PSA and testosterone (z = 0.04, 95% CI: −0.04 to 0.12, P = .04; r = 0.039). However, in the subgroup of non‐BPH (benign prostate hyperplasia), a significant correlation between PSA and testosterone (z = 0.07, 95% CI: 0.01‐0.13, P = .009; r = 0.089) was found. Conclusions We found that TRT, particularly IM TRT, significantly changed the PSA level compared with the placebo group. Furthermore, there was a significant correlation between PSA and testosterone in patients with non‐BPH. According to these findings, we suggest the possibility of PSA as a surrogate marker of testosterone.

show abstract

“…Fatique is one of the symptoms of diabetes as patients are easily tired after little work, so it is not surprising the respondents were attributing fatique as one of the factors leading to post diabetes sexual dysfunction. Studies have shown the association between levels of testosterone in diabetic men and their desire for sex [15,16,17,18] . Men with diabetes often experience blood vessel damages which affect blood flow to the penis and also nerve damages making it more difficult for them to maintain erection [19] .…”

Section: Discussionmentioning

confidence: 99%

Post-Diabetes Sexual Behavioural Changes Among Male Type-2 Diabetes Patients in South-West Nigeria

Agofure

Odjimogho²,

Efegbere

et al. 2019

Journal of Biochemistry and Molecular Biology Research

View full text Add to dashboard Cite

Studying the effect of diabetes mellitus type 2 on prostate related parameters: A prospective single institutional study

Cited by 6 publications

References 0 publications

The correlation between obesity and prostate volume in patients with benign prostatic hyperplasia at Charlotte Maxeke Johannesburg Academic Hospital

The correlation between obesity and prostate volume in patients with benign prostatic hyperplasia at Charlotte Maxeke Johannesburg Academic Hospital

Association between prostate‐specific antigen and serum testosterone: A systematic review and meta‐analysis

Post-Diabetes Sexual Behavioural Changes Among Male Type-2 Diabetes Patients in South-West Nigeria

Contact Info

Product

Resources

About