Studying the effect of 0.14 THz radiation on human dermal fibroblasts

Черкасова, О. П.; Суровцева, М. А.; Лыков, А. П.; Kazakov, O. V.; Kabakov, Alexander E.; Повещенко, О. В.; Повещенко, А. Ф.; Serdyukov, Danil S.; Kuznetsov, S. А.; Letyagin, A. Yu.

doi:10.1063/1.5098148

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…114 Studies performed on skin cells showed no signs of apoptosis and oxidative stress. 115 On the other hand, there are data regarding THz-induced adipogenic differentiation of melanoma skin cancer MSCs and indications that THz can influence on the protein transcription. 116,117 More detailed data are presented in Table 1.…”

Section: Effects Of Thz Radiation On the Skinmentioning

confidence: 99%

Terahertz radiation and the skin: a review

et al. 2021

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Significance: Terahertz (THz) radiation has demonstrated a great potential in biomedical applications over the past three decades, mainly due to its non-invasive and label-free nature. Among all biological specimens, skin tissue is an optimal sample for the application of THz-based methods because it allows for overcoming some intrinsic limitations of the technique, such as a small penetration depth (0.1 to 0.3 mm for the skin, on average). Aim: We summarize the modern research results achieved when THz technology was applied to the skin, considering applications in both imaging/detection and treatment/modulation of the skin constituents. Approach: We perform a review of literature and analyze the recent research achievements in THz applications for skin diagnosis and investigation. Results: The reviewed results demonstrate the possibilities of THz spectroscopy and imaging, both pulsed and continuous, for diagnosis of skin melanoma and non-melanoma cancer, dysplasia, scars, and diabetic condition, mainly based on the analysis of THz optical properties. The possibility of modulating cell activity and treatment of various diseases by THz-wave exposure is shown as well. Conclusions: The rapid development of THz technologies and the obtained research results for skin tissue highlight the potential of THz waves as a research and therapeutic instrument. The perspectives on the use of THz radiation are related to both non-invasive diagnostics and stimulation and control of different processes in a living skin tissue for regeneration and cancer treatment.

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Section: Effects Of Thz Radiation On the Skinmentioning

confidence: 99%

Terahertz radiation and the skin: a review

et al. 2021

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“…Some of these demonstrations prove the effect of THz radiation on blood cells [237]- [241], skin cells [242]- [246], and nerve cells [247]- [249]. However, others studies did not report a negative impact on blood cells [238], [250], [251], skin cells [252], [253], and nerve cells [254]. [236] summarizes the data concerning the effects of THz radiation on cells; the conclusion is that THz radiation can indeed affect biological cells through modifications to the membranes, proliferation, and pore formation.…”

Section: Effects Of Terahertz Radiation On Healthmentioning

confidence: 99%

Body-Centric Terahertz Networks: Prospects and Challenges

Saeed

Loukil

Sarieddeen

et al. 2022

IEEE Trans. Mol. Biol. Multi-Scale Commun.

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Following recent advancements in Terahertz (THz) technology, THz communications are currently being celebrated as key enablers for various applications in future generations of communication networks. While typical communication use cases are over medium-range air interfaces, the inherently small beamwidths and transceiver footprints at THz frequencies support nano-communication paradigms. In particular, the use of the THz band for in-body and on-body communications has been gaining attention recently. By exploiting the accurate THz sensing and imaging capabilities, body-centric THz biomedical applications can transcend the limitations of molecular, acoustic, and radio-frequency solutions. In this paper, we study the use of the THz band for body-centric networks, by surveying works on THz device technologies, channel and noise modeling, modulation schemes, and networking topologies. We also promote THz sensing and imaging applications in the healthcare sector, especially for detecting zootonic viruses such as Coronavirus. We present several open research problems for body-centric THz networks.

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“…244,245 In Ref. 246, HDFs were exposed, for 20 min, to the CW THz radiation, with the frequency of 0.14 THz and the irradiance of 35 to 354 mW∕cm 2 . Such parameters as proliferative activity, wound closure percentage, and the level of nitric oxide production in the irradiated cells were estimated.…”

Section: Skin and Cornea Cellsmentioning

confidence: 99%

“…Therefore, lowfrequency THz radiation does not affect the functional activity of the HDFs. 246 In Ref. 247, human skin fibroblasts (NB1RGB cell line) and human corneal epithelial cells (HCE-T cell line) were exposed, for 3, 70, and 94 h, to the CW THz radiation, with the tunable output frequency in the range of 0.07 to 0.3 THz and the irradiance of 0.4 to 1.3 μW∕cm 2 .…”

Section: Skin and Cornea Cellsmentioning

confidence: 99%

Cellular effects of terahertz waves

et al. 2021

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. Significance: An increasing interest in the area of biological effects at exposure of tissues and cells to the terahertz (THz) radiation is driven by a rapid progress in THz biophotonics, observed during the past decades. Despite the attractiveness of THz technology for medical diagnosis and therapy, there is still quite limited knowledge about safe limits of THz exposure. Different modes of THz exposure of tissues and cells, including continuous-wave versus pulsed radiation, various powers, and number and duration of exposure cycles, ought to be systematically studied. Aim: We provide an overview of recent research results in the area of biological effects at exposure of tissues and cells to THz waves. Approach: We start with a brief overview of general features of the THz-wave–tissue interactions, as well as modern THz emitters, with an emphasis on those that are reliable for studying the biological effects of THz waves. Then, we consider three levels of biological system organization, at which the exposure effects are considered: (i) solutions of biological molecules; (ii) cultures of cells, individual cells, and cell structures; and (iii) entire organs or organisms; special attention is devoted to the cellular level. We distinguish thermal and nonthermal mechanisms of THz-wave–cell interactions and discuss a problem of adequate estimation of the THz biological effects’ specificity. The problem of experimental data reproducibility, caused by rareness of the THz experimental setups and an absence of unitary protocols, is also considered. Results: The summarized data demonstrate the current stage of the research activity and knowledge about the THz exposure on living objects. Conclusions: This review helps the biomedical optics community to summarize up-to-date knowledge in the area of cell exposure to THz radiation, and paves the ways for the development of THz safety standards and THz therapeutic applications.

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Studying the effect of 0.14 THz radiation on human dermal fibroblasts

Cited by 9 publications

References 20 publications

Terahertz radiation and the skin: a review

Terahertz radiation and the skin: a review

Body-Centric Terahertz Networks: Prospects and Challenges

Cellular effects of terahertz waves

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