Studying the dissolution of immediate release film coating using terahertz pulsed imaging

Dong, Runqiao; Nassar, M.; Friend, Barry; Teckoe, Jason; Zeitler, J. Axel

doi:10.1016/j.ijpharm.2022.122456

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…However, it has been proved that the coating can control the dissolution rate. As reported in the literature [ 30 ], several stages are involved in the dissolution of the coating layer, which activates the tablet disintegration process, such as hydration, swelling, and then the entrance of water into the core tablet. It has been reported that the wetted coating can act as a barrier to the diffusion of water in the core, influencing the disintegration and therefore the dissolution rate [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…As reported in the literature [ 30 ], several stages are involved in the dissolution of the coating layer, which activates the tablet disintegration process, such as hydration, swelling, and then the entrance of water into the core tablet. It has been reported that the wetted coating can act as a barrier to the diffusion of water in the core, influencing the disintegration and therefore the dissolution rate [ 30 ]. To determine the effect of ageing on the performance of Opadry_O coating, tablets made of microcrystalline cellulose, crospovidone and sodium stearyl fumarate were prepared and coated with a Opadry_O coating; the disintegration times of these tablets were measured ( Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

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Investigation into the Influence of the Process Parameters on the Stability of a Poly(Vinyl)-Alcohol-Based Coating System

Canale,

Paleari,

Bragaglia

et al. 2024

Molecules

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Most tablets put on the market are coated with polymers soluble in water. The Opadry II 85 series from Colorcon Inc., is a family of PVA-based products marketed since the 1990s. Despite numerous publications on the properties of PVA, to date, limited work has been undertaken to determine the physico-chemical parameters (i.e., UV light, high temperature, and relative humidity) that could affect the performance of PVA-based coatings. To this end, we performed artificial ageing processes on samples made of Opadry Orange II or of some selected components of this coating and analysed them by means of a multidisciplinary approach, using, for example, FTIR, NMR, rheology, and DMTA measurements. In this way, we analysed the influence of the critical components of the Opadry Orange II formula, such as titanium dioxide and aluminium hydroxide, on the coating characteristics under ageing conditions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Investigation into the Influence of the Process Parameters on the Stability of a Poly(Vinyl)-Alcohol-Based Coating System

Canale,

Paleari,

Bragaglia

et al. 2024

Molecules

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“…Analyzing the effect of coating thickness on dissolution and corresponding adjustments can make the enteric-coated tablets conform to specific in vivo release requirements. There are various methods for determining coating thickness, including near-infrared spectroscopy (NIRS) ( De Beer et al, 2011 ; Gendre et al, 2011 ; Avalle et al, 2014 ; Korasa et al, 2016 ; Hattori et al, 2018 ; Wahl et al, 2019 ; Mohan et al, 2020 ), Raman spectroscopy ( Muller et al, 2012 ; Wirges et al, 2013 ; Kim et al, 2016 ; Barimani and Peter, 2017 ), optical coherence tomography ( Markl et al, 2015a ; Markl et al, 2015b ; Sacher et al, 2019 ; Matthias et al, 2022 ), terahertz pulsed imaging ( Brock et al, 2012 ; Lin et al, 2017 ; Pei et al, 2018 ; Dong et al, 2023 ), X-ray computed tomography (X-CT) ( Ariyasu et al, 2017 ), and multispectral UV imaging ( Novikova et al, 2017 ). Compared with conventional methods of calculating thickness by weight gain after coating, these methods enable direct measurement of coating thickness and can also be used for online control of the coating process.…”

Section: Introductionmentioning

confidence: 99%

Characterization of enteric-coated erythromycin tablets by Raman mapping and its pharmaceutical evaluation

Zou,

Liu,

2023

Front. Chem.

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Enteric tablet coating thickness is a critical quality attribute of the coating process that can affect dissolution behavior in vitro as well as release in vivo. Raman mapping offers unique advantages in analyzing the distribution of active pharmaceutical ingredients and excipients in formulations. In this study, Raman mapping was used to characterize the coating of enteric-coated erythromycin tablets coated by two different processes and compare the differences in their coating formulation, thickness, and uniformity. Furthermore, we aimed to select the appropriate pH of the dissolution medium at which the coating slowly cracks to release the drug and determine the dissolution profile. The differences in the coating thickness and uniformity of the two products resulted in differences in dissolution behavior. Although there are differences in the coating processes for the two types of enteric-coated erythromycin tablets, the thickness of the outer coating on the side is a critical quality attribute in both processes. The outer coating of product A is relatively thick, and the thickness of the outer coating on the side affects the dissolution amount. The outer coating of product B is relatively thin, resulting in a short cracking time and large variation and a significant difference in the initial dissolution amounts between tablets. Raman mapping can be used to analyze the differences in coating formulations and for process evaluation.

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Terahertz Radiation Detectors Using CMOS Compatible SOI Substrates

Hasan,

Khan,

Shahzadi

et al. 2024

Adv Funct Materials

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In recent years, silicon‐based room temperature Terahertz (THz) detectors have become the most optimistic research area because of their high speed, low cost, and unimpeded compatibility with mainstream complementary metal‐oxide‐semiconductor (CMOS) device technologies. However, Silicon (Si) suffers from low responsivity and high noise at THz frequencies. In this review, the recent advances in Si‐based THz detectors using silicon‐on‐insulator (SOI) substrates are presented. These offer several advantages over bulk counterparts, such as reduced parasitic capacitance, enhanced electric field confinement, and improved thermal isolation. The different types of THz detectors exploiting SOI substrate, such as conventional metal‐oxide‐semiconductor field effect transistors (MOSFETs), junction‐less MOSFETs, junction‐less nanowires field effect transistors (JLNWFETs), micro‐electromechanical system (MEMS), metal‐semiconductor‐metal (MSM) structures, and single electron transistor (SET), are discussed, and their key performances in terms of responsivity, noise equivalent power (NEP), bandwidth, and dynamic range are compared. The challenges and opportunities for further improvement of SOI THz detectors, such as device scaling, integration, and modulation, are also highlighted. This review may offer compelling evidence supporting the idea that SOI THz detectors have the potential to facilitate high performance, low power consumption, and scalability—qualities essential for advancing next‐level technologies.

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Studying the dissolution of immediate release film coating using terahertz pulsed imaging

Cited by 5 publications

References 25 publications

Investigation into the Influence of the Process Parameters on the Stability of a Poly(Vinyl)-Alcohol-Based Coating System

Investigation into the Influence of the Process Parameters on the Stability of a Poly(Vinyl)-Alcohol-Based Coating System

Characterization of enteric-coated erythromycin tablets by Raman mapping and its pharmaceutical evaluation

Terahertz Radiation Detectors Using CMOS Compatible SOI Substrates

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