Sesame is an erect herbaceous annual plant with both single-stemmed and branched growth habits. Sesame seed yield is easily affected by soil moisture stress in semi-arid climate. Good vertisol management options that conserve moisture during dry spell period and drain excess moisture during wet periods is vital. Study area has limited rainfall therefore evidences on effect of land configuration ways on soil moisture and sesame yield is critical. A field investigation was conducted at Humera Agricultural Research Center (HuARC) during 2016 growing season in vertisol soil type. The experiment was laid out by randomized complete block design (RCBD) with three replication that consists of three land configuration ways or methods namely flat, ridge and furrow, and bed furrow. Sesame variety, Setit-1, was sown with 40 cm and 10 cm spacing between rows and plants respectively. The analysis revealed that land configuration methods had a significant effect on soil moisture and agronomic parameter. The highest sesame seed yield (558 kg ha-1) was recorded at ridge and furrow, while the lowest (400 kg ha-1) was found at the flat land configuration method. The ridge and furrow methods conserved best soil moisture for highest plant and seed yield performance.