Background: An important key to a hospital's long-term competitiveness is the ability of head nurses to handle their role as leaders in daily work. To do so, head nurses must have resilience in their ways of working and encouraging innovation behaviors among nurses is already critical development direction for healthcare to prevent work alienation. Aim: To assess the influence of head nurses' resilience on emergency nurses' innovative behavior and work alienation. Methods: The design was descriptive correlational. Three tools are used for data collection; Nurses' Perception for Head Nurses' Resilience Questionnaire, Nurses' Innovative Behavior Questionnaire and Work Alienation Questionnaire. Results: Nurses perceived high level of head nurses' resilience and innovative behavior, while majority of them were perceived low level of work alienation. Additionally, there was a highly positive statistically significant correlation between head nurses' resilience and nurses' innovative behavior. While, there is a negative statistically significant correlation between nurses' innovative behavior and work alienation. As well no statistically significant correlation between head nurses' resilience and work alienation. Conclusion: Head nurses' resilience improves nurses' innovative behavior. Recommendations: Critical follow up to strengthen head nurses' resilience abilities and monitor nurses' work innovative behaviors development, as well as to assess the work alienation level on a regular basis and build up suitable intervention to cope with these situations.