Studying of Preventive and Medical Effectiveness of Bacteriophages’ Preparation at Mastitis of Cows in the Conditions of Lactic and Commodity Farm

In the scientific and practical fields of dairy farming a lot of attention is given to pathologies and diseases of cow’s mammary gland. Mastitis, as a nosological unit, is an actual targeted direction for many researchers. The development of preventive and therapeutic medicines based on bacteriophages is a promising and demanded direction in dairy farming. In the course of work was shown reactogenicity of mammary gland after the intracisternally administration of viral antigen. It was manifested by vividly expressed clinical signs of serous-fibrinous inflammation. The described reaction is very similar to the manifestation of a non-specific antiviral immune response. It was noted the dose-dependent intensity of the somatic reaction and clinical manifestations of a non-specific response when inactivated bacteriophages were administrated. The clinical manifestation of a non-specific protective antiviral mechanism of the mammary gland in response to the administration of bacteriophages was shown too. Method of phage-mediated sensitization of the mammary gland was proposed for the first time.

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Bacteriophage-mediated sensibilization of mammary gland

Glazunov¹,

Pimenov

Pustovit

2020

IOP Conf. Ser.: Earth Environ. Sci.

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Study of the effect of the drug “Primalact” on the organism and mammary gland of lactating cows

Bryukhova¹,

Klimov²,

Хохлова³

et al. 2020

Agrarian Bulletin of The

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Abstract. The problem of prevention and treatment of mammary gland diseases in cows does not lose its relevance at the present time. Therefore, the veterinary pharmacologists face the task of developing new drugs to combat mastitis, which have a wide spectrum of antimicrobial activity and minimal side effects. The propose of the study was to assess the effect of the complex antibacterial drug “Primalact” on the clinical status, morphological and biochemical blood indicators of lactating cows and the detection of irritating effect on the mammary gland tissue. Methodology and methods. After intracisternal administration of “Primalact” at therapeutic (5 ml) and three-fold therapeutic (15 ml) doses, the general clinical condition of the animals and the state of the mammary gland tissues were analyzed, the change in the qualitative indicators of the udder secretion by the content of somatic cells and in the reaction with Masttest was evaluated. The results obtained during the experiment were statistically processed. Results. Examination data showed the absence of significant changes in the clinical condition of experimental animals and mammary gland tissue 12, 24, 48, and 72 hours after the use of “Primalact”. The results of blood morpho-biochemical analysis indicate the absence of significant changes in 72 hours. The reaction of the udder secretion with Masttest and the analysis of the content of somatic cells in milk of animals of both groups revealed the presence of a slightly irritating effect in the studied drug, terminating to 72 hours after application. According to the data of R. Miller (1977), drugs for intracisternal administration, which cause slight irritation of mammary gland tissue for a period of not more than 96 hours, are suitable for the treatment of mastitis in cows.

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Studying of Preventive and Medical Effectiveness of Bacteriophages’ Preparation at Mastitis of Cows in the Conditions of Lactic and Commodity Farm

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Bacteriophage-mediated sensibilization of mammary gland

Bacteriophage-mediated sensibilization of mammary gland

Study of the effect of the drug “Primalact” on the organism and mammary gland of lactating cows

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