Studying Network Mechanisms Using Intracranial Stimulation in Epileptic Patients

David, Olivier; Bastin, Julien; Chabardès, Stéphan; Minotti, Lorella; Kahane, Philippe

doi:10.3389/fnsys.2010.00148

Cited by 75 publications

(54 citation statements)

References 119 publications

(165 reference statements)

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“…causing hand movements during stimulation of the motor cortex), inhibit a brain region (e.g. causing language arrest during stimulation of Broca's area), or activate a whole sub-network distant to the site of stimulation (David et al, 2010;Mandonnet et al, 2010). Therefore, the experience of fear during stimulation of the amygdala may result from activation of the amygdala itself, may result from activation of a distant brain region via neural connections, or conversely may result from disinhibition of a distant brain region by inhibition of the amygdala.…”

Section: Limitations Of Hie Techniquesmentioning

confidence: 99%

Exploring emotions using invasive methods: review of 60 years of human intracranial electrophysiology

Guillory

Bujarski

2014

Social Cognitive and Affective Neuroscience

112

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Over the past 60 years, human intracranial electrophysiology (HIE) has been used to characterize seizures in patients with epilepsy. Secondary to the clinical objectives, electrodes implanted intracranially have been used to investigate mechanisms of human cognition. In addition to studies of memory and language, HIE methods have been used to investigate emotions. The aim of this review is to outline the contribution of HIE (electrocorticography, single-unit recording and electrical brain stimulation) to our understanding of the neural representations of emotions. We identified 64 papers dating back to the mid-1950s which used HIE techniques to study emotional states. Evidence from HIE studies supports the existence of widely distributed networks in the neocortex, limbic/paralimbic regions and subcortical nuclei which contribute to the representation of emotional states. In addition, evidence from HIE supports hemispheric dominance for emotional valence. Furthermore, evidence from HIE supports the existence of overlapping neural areas for emotion perception, experience and expression. Lastly, HIE provides unique insights into the temporal dynamics of neural activation during perception, experience and expression of emotional states. In conclusion, we propose that HIE techniques offer important evidence which must be incorporated into our current models of emotion representation in the human brain.

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Section: Limitations Of Hie Techniquesmentioning

confidence: 99%

Exploring emotions using invasive methods: review of 60 years of human intracranial electrophysiology

Guillory

Bujarski

2014

Social Cognitive and Affective Neuroscience

112

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“…For example, electrical stimulation affects all cell types, including not only excitatory and inhibitory neurons but also glial cells such as astrocytes (Vedam-Mai et al 2012), which are thought to play an important role in seizure generation (Clasadonte and Haydon 2012). It can also stimulate fibers of passage and result in antidromic neuronal activation (David et al 2010), likely resulting in the activation of sparse and distributed neuronal populations (Histed et al 2009). Optogenetic techniques, or the control of genetically targeted neuronal populations by light (Yizhar et al 2011a), enable us to circumvent these limitations.…”

mentioning

confidence: 99%

Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy

Wagner

Truccolo

Wang

et al. 2015

Journal of Neurophysiology

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Wagner FB, Truccolo W, Wang J, Nurmikko AV. Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy. J Neurophysiol 113: 2321-2341, 2015. First published December 31, 2014 doi:10.1152/jn.01040.2014.-Transitions into primary generalized epileptic seizures occur abruptly and synchronously across the brain. Their potential triggers remain unknown. We used optogenetics to causally test the hypothesis that rhythmic population bursting of excitatory neurons in a local neocortical region can rapidly trigger absence seizures. Most previous studies have been purely correlational, and it remains unclear whether epileptiform events induced by rhythmic stimulation (e.g., sensory/ electrical) mimic actual spontaneous seizures, especially regarding their spatiotemporal dynamics. In this study, we used a novel combination of intracortical optogenetic stimulation and microelectrode array recordings in freely moving WAG/Rij rats, a model of absence epilepsy with a cortical focus in the somatosensory cortex (SI). We report three main findings: 1) Brief rhythmic bursting, evoked by optical stimulation of neocortical excitatory neurons at frequencies around 10 Hz, induced seizures consisting of self-sustained spikewave discharges (SWDs) for about 10% of stimulation trials. The probability of inducing seizures was frequency-dependent, reaching a maximum at 10 Hz. 2) Local field potential power before stimulation and response amplitudes during stimulation both predicted seizure induction, demonstrating a modulatory effect of brain states and neural excitation levels. 3) Evoked responses during stimulation propagated as cortical waves, likely reaching the cortical focus, which in turn generated self-sustained SWDs after stimulation was terminated. Importantly, SWDs during induced and spontaneous seizures propagated with the same spatiotemporal dynamics. Our findings demonstrate that local rhythmic bursting of excitatory neurons in neocortex at particular frequencies, under susceptible ongoing brain states, is sufficient to trigger primary generalized seizures with stereotypical spatiotemporal dynamics.

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“…The intracranial interictal electrical activity is typical for FCD type II b, recognized as a common cause of drug resistant epilepsy in pediatric population and commonly overlooked at routine inspection of MRI images, being considered MRI negative (2,5). …”

Section: Discussionmentioning

confidence: 99%

“…Stimulation of the implanted structures was performed, aiming the study of the epileptogenic network, delineation of the eloquent cortex or inducing habitual seizures (5). Electrical stimuli (1Hz, 3ms and 50Hz, 1ms rectangular biphasic pulses) were applied to adjacent contacts, using a programmable stimulator (Guideline LP+, FHC Inc).…”

mentioning

confidence: 99%

Presurgical evaluation and epilepsy surgery in MRI negative resistant epilepsy of childhood with good outcome

Craiu

Barborică²,

Motoescu³

et al. 2015

Turkish Neurosurgery

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Magnetic resonance imaging (MRI)-negative epilepsy may be successfully solved with a multidisciplinary approach using invasive recordings, image and signal analysis. The whole methodology used by the epilepsy surgery team is systematically described based on an resistant epilepsy case with all steps and rationale of choosing different investigation methods from surface electroencephalography (EEG) to invasive recordings. Due to negative MRI and non-concordant ictal surface EEG with clinical semiology, the patient was investigated with stereo-EEG (SEEG), aiming to delimitate epileptogenic and eloquent cerebral areas. Implantation strategy, seizures recordings, stimulation, resection planning using quantitative EEG analysis, and the surgery plan are presented. The patient has been seizure-free for 14 months so far, with improved behavior and daily life quality. Post-operative examination revealed focal cortical dysplasia type II B.KeywOrds: Epilepsy surgery, Focal cortical dysplasia, MRI-negative postsurgical outcome, Resistant epilepsy, Stereo-EEG ÖZManyetik rezonans görüntüleme (MRG)-negatif epilepsi, invaziv kayıt alma, görüntü ve sinyal analizini kapsayan mültidisipliner bir yaklaşımla başarılı bir şekilde tedavi edilebilir. Dirençli bir epilepsi olgusu temelinde epilepsi cerrahisi ekibinde kullanılan tüm metodoloji tüm basamakları ile, yüzey elektroensefalografisinden (EEG) invaziv kayıt almaya kadar değişik inceleme teknikleri arasından uygun olanı seçilerek, tanımlanmıştır. Olgu MRG negatif olduğu ve klinik tablo ile iktal yüzey EEG uyumsuz olduğu için stereo-EEG (SEEG) kullanılarak epileptojenik bölgeler ile fonksiyonel beyin alanlarının ayırt edilmesi hedeflenmiştir. Bu olgunun implantasyon stratejisi, nöbet kayıtları, stimülasyon, kantitatif EEG analizi ile rezeksiyon planlaması ve cerrahi planı sunulmuştur. Hastada 14 ay boyunca nöbet izlenmemiştir, davranışları ve günlük yaşam kalitesi düzelmiştir. Postoperatif inceleme Tip II B fokal kortikal displazi olduğunu göstermiştir.AnAhtAr sÖZCÜKler: Epilepsi cerrahisi, Fokal kortikal displazi, MRG-negatif cerrahi sonrası sonuç, Dirençli epilepsi, Stereo-EEG

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Studying Network Mechanisms Using Intracranial Stimulation in Epileptic Patients

Cited by 75 publications

References 119 publications

Exploring emotions using invasive methods: review of 60 years of human intracranial electrophysiology

Exploring emotions using invasive methods: review of 60 years of human intracranial electrophysiology

Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy

Presurgical evaluation and epilepsy surgery in MRI negative resistant epilepsy of childhood with good outcome

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