Studying Microcirculation with Micro‐CT

Kline, Timothy L.; Ritman, Erik L.

doi:10.1002/9783527651238.ch14

Cited by 3 publications

(4 citation statements)

References 62 publications

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“…; Schambach et al. ; Kline & Ritman, ). These 3D images are also more conveniently susceptible to analysis of the intact in situ vasculature.…”

Section: Introductionmentioning

confidence: 99%

“…We therefore used micro-CT to image contrast-enhanced vasculature of intact rat livers. Micro-CT is an excellent method for studying the anatomy of the branching geometry of microvasculature by allowing high-resolution 3D images to be generated in intact specimens (Wan et al 2000;Marxen et al 2004;Schambach et al 2010;Kline & Ritman, 2012). These 3D images are also more conveniently susceptible to analysis of the intact in situ vasculature.…”

Section: Introductionmentioning

confidence: 99%

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Anatomy of hepatic arteriolo‐portal venular shunts evaluated by 3D micro‐CT imaging

et al. 2014

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The liver differs from other organs in that two vascular systems deliver its blood -the hepatic artery and the portal vein. However, how the two systems interact is not fully understood. We therefore studied the microvascular geometry of rat liver hepatic artery and portal vein injected with the contrast polymer Microfil â .Intact isolated rat livers were imaged by micro-CT and anatomic evidence for hepatic arteriolo-portal venular shunts occurring between hepatic artery and portal vein branches was found. Simulations were performed to rule out the possibility of the observed shunts being artifacts resulting from image blurring. In addition, in the case of specimens where only the portal vein was injected, only the portal vein was opacified, whereas in hepatic artery injections, both the hepatic artery and portal vein were opacified. We conclude that mixing of the hepatic artery and portal vein blood can occur proximal to the sinusoidal level, and that the hepatic arteriolo-portal venular shunts may function as a one-way valve-like mechanism, allowing flow only from the hepatic artery to the portal vein (and not the other way around).

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“…; Schambach et al. ; Kline & Ritman, ). These 3D images are also more conveniently susceptible to analysis of the intact in situ vasculature.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anatomy of hepatic arteriolo‐portal venular shunts evaluated by 3D micro‐CT imaging

et al. 2014

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“…Resultantly, small vessel diameters appear to broaden and this causes inaccuracies in CT-values. However, improvements in scanner components have made bench-top nano-CT units feasible, having the ability to image at cellular and subcellular levels with voxel resolutions on the order of 500 nm [249]. Micro-CT provides high resolution 3D volumetric data, suitable for analysis, quantification, validation and visualisation of vasculature.…”

Section: Micro-computed Tomographymentioning

confidence: 99%

“…the potential for radiation damage to the specimen, thereby altering the physiology). High spatial resolution requires high doses, and a reduction in dose causes higher image noise and reduced image contrast [249].…”

Section: Micro-computed Tomographymentioning

confidence: 99%

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

Daly

Leahy

2012

Journal of Biophotonics

107

108

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Physics has delivered extraordinary developments in almost every facet of modern life. From the humble thermometer and stethoscope to X‐Ray, CT, MRI, ultrasound, PET and radiotherapy, our health has been transformed by these advances yielding both morphological and functional metrics. Recently high resolution label‐free imaging of the microcirculation at clinically relevant depths has become available in the research domain. In this paper, we present a comprehensive review on current imaging techniques, state‐of‐the‐art advancements and applications, and general perspectives on the prospects for these modalities in the clinical realm. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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- Advances in Blood Flow Imaging

Tuchin¹

2016

Advanced Biophotonics

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Studying Microcirculation with Micro‐CT

Cited by 3 publications

References 62 publications

Anatomy of hepatic arteriolo‐portal venular shunts evaluated by 3D micro‐CT imaging

Anatomy of hepatic arteriolo‐portal venular shunts evaluated by 3D micro‐CT imaging

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

- Advances in Blood Flow Imaging

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