Recently, several B-physics experiments report interesting anomalies in the semileptonic decays of B-mesons, such as the excess in the R D ( * ) measurements. These anomalies seem to suggest intriguing hints of lepton flavor non-universality, and the R-parity violating (RPV) interactions are candidates for explaining this nonuniversality. In this paper, we discuss the RPV interactions for resolving the R D ( * ) anomaly with the Grand Unified Theory (GUT) assumption. To solve the R D ( * ) anomaly, it is known that large RPV couplings and around 1 TeV sfermion masses are required. At the same time, large RPV couplings are conducive to realize the bottom-tau Yukawa unification which appears in the GUT models. On the other hand, there are problems for realizing favorable sfermion masses in the constrained minimal supersymetric standard model. To resolve these problems, we show that two non-universalities, the non-universal sfermion masses and the non-universal gaugino masses, are favorable.Recently, several interesting anomalies in semi-leptonic B-meson decays are reported by the B-physics experiments. For example, the ratios of the branching fractions1) where l = e, µ, have been measured by the BaBar [1], Belle [2], and LHCb [3] collaborations and show large deviations from the Standard Model (SM) predictions. These ratios are ideal observables for testing the SM, especially the lepton flavor universality, because they are independent of the Cabibbo-Kobayashi-Maskawa (CKM) matrix element V cb and are free from the experimental and theoretical uncertainties common to the numerator and the denominator. The most recent averages of the BaBar, Belle, and LHCb measurements, as compiled by the Heavy Flavor Averaging Group [4], read [5]