Studying food entrainment: Models, methods, and musings

Trzeciak, Jacqueline R.; Steele, Andrew D.

doi:10.3389/fnut.2022.998331

Cited by 5 publications

(4 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, animals live in complex temporal environments, and their circadian system can be entrained by non-photic zeitgebers as well (13,14). A classic example of this non-photic entrainment is time-restricted feeding, which leads to activity in anticipation of feeding events and is the result of entrainment by a food-entrainable oscillator(s) (FEO) (15,16). Here, we show that cyclic fear is similarly effective in entraining circadian rhythms.…”

Section: Discussionmentioning

confidence: 72%

The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment in the mouse

Bussi

Ben-Hamo

Leon

et al. 2023

Preprint

View full text Add to dashboard Cite

Nocturnal aversive stimuli presented to mice during eating and drinking outside of their safe nest can entrain circadian behaviors, leading to a shift toward daytime activity. We show that the canonical molecular circadian clock is necessary for fear entrainment and that an intact molecular clockwork in the suprachiasmatic nucleus (SCN), the site of the central circadian pacemaker, is necessary but not sufficient to sustain fear entrainment of circadian rhythms. Our results demonstrate that entrainment of a circadian clock by cyclic fearful stimuli can lead to severely mistimed circadian behavior that persists even after the aversive stimulus is removed. Together, our results support the interpretation that circadian and sleep symptoms associated with fear and anxiety disorders may represent the output of a fear-entrained clock.

show abstract

Section: Discussionmentioning

confidence: 72%

The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment in the mouse

Bussi

Ben-Hamo

Leon

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…During these experiments, animals were fed every 72-hours, with the timing of feeding coinciding with the second day of each lighting regime. Feeding has the potential to act as a strong entrainment factor (Shibata et al, 2010;Carneiro and Araujo, 2012;Trzeciak and Steele, 2022), potentially influencing results. The short time frame of this study (72-hours for each lighting regime) also limits a full assessment of the longer-term effects of light on elasmobranch activity.…”

Section: The Influence Of Light On Elasmobranch Behaviormentioning

confidence: 99%

The influence of light on elasmobranch behavior and physiology: a review

Carroll,

Harvey-Carroll

2023

Front. Mar. Sci.

View full text Add to dashboard Cite

In this review, we summarize the state of knowledge of the influence of light on the activity and physiology of elasmobranchs (sharks, skates, rays, and sawfish). These are a diverse group with great economic and ecological importance. The long-term success of a species is largely determined by its ability to respond to changes in its environment. Light plays an important role for many marine species in signaling rhythmic environmental changes which are part of daily and annual cycles. Behavioral and physiological changes by organisms in response to these signals have evolved enabling them to maximize survival and reproductive success. In an environment with increased levels of artificial light at night (ALAN), deleterious changes in activity and physiology can occur. By summarizing what is known about the influence of light on elasmobranch activity, it can be concluded that ALAN is likely to have a negative impact on elasmobranchs at the individual and population level. We also discuss the example of intentional nocturnal light pooling by the tourism industry to attract whale sharks (Rhincodon typus) and manta rays (Mobula spp.) and recommend regulation of this activity.

show abstract

“…Here, we used a time-and calorie-restricted feeding paradigm to rapidly induce food entrainment in mice (22), with a focus on the SCN and the dorsomedial hypothalamus (DMH) that are involved in the regulation of feeding, locomotor activity, sleep-wake cycles, and hormone rhythms (23)(24)(25)(26). By using single-nucleus RNA sequencing (snRNA-seq), we sought to identify neuronal populations in the SCN and DMH that show changes in circadian transcriptional programs.…”

Section: Introductionmentioning

confidence: 99%

Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network

Tang,

Godschall,

Brennan

et al. 2023

Sci. Adv.

View full text Add to dashboard Cite

Salient cues, such as the rising sun or availability of food, entrain biological clocks for behavioral adaptation. The mechanisms underlying entrainment to food availability remain elusive. Using single-nucleus RNA sequencing during scheduled feeding, we identified a dorsomedial hypothalamus leptin receptor–expressing (DMH LepR ) neuron population that up-regulates circadian entrainment genes and exhibits calcium activity before an anticipated meal. Exogenous leptin, silencing, or chemogenetic stimulation of DMH LepR neurons disrupts the development of molecular and behavioral food entrainment. Repetitive DMH LepR neuron activation leads to the partitioning of a secondary bout of circadian locomotor activity that is in phase with the stimulation and dependent on an intact suprachiasmatic nucleus (SCN). Last, we found a DMH LepR neuron subpopulation that projects to the SCN with the capacity to influence the phase of the circadian clock. This direct DMH LepR -SCN connection is well situated to integrate the metabolic and circadian systems, facilitating mealtime anticipation.

show abstract

Studying food entrainment: Models, methods, and musings

Cited by 5 publications

References 108 publications

The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment in the mouse

The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment in the mouse

The influence of light on elasmobranch behavior and physiology: a review

Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network

Contact Info

Product

Resources

About