Study the Interaction Adsorptive Behavior of Sunset Yellow Dye and Loratadine Drug: Kinetics and Thermodynamics Study

Abstract

The performance of drug treatment and assessments of different drugs' side effects both can be affected by the interaction between food additives and drugs. Organic compounds such as food colorants dyes are utilized as additives in a wide range of foods. In this study, the adsorption interaction behavior between the colorant food dye sunset yellow (SY) and the drug loratadine was examined. The adsorption procedure is conducted at different drug dosages, various SY dye concentrations, and different temperature (288-318K). The equilibrium data were explained by using Freundlich and Langmuir adsorption isotherms, but Langmuir offering the best fit model. Kinetics adsorptive behavior of sunset yellow on loratadine matched pseudo-second order kinetics. Thermodynamics study show that the process is exothermic, spontaneous and the disorder at the solid-solution interface was proven from the negative entropy (-140.556 J/ K.mol) of adsorption process.

الايزوثيرمات والدوال الدينميكية الحرارية لامتزاز دواء الميتوبرولول على السليكا متوسطة المسام المحضرة

“…Higher negative values represent an adsorption process that is more energy-beneficial, and the ∆G° measures the spontaneity of the adsorption process. The study's negative ∆G° values at all temperatures under investigation attest to the adsorbent's viability and the spontaneity of adsorption 28,29 .…”

“…The n value shows the degree of nonlinearity between solution concentration and adsorption. According to Table 2, the range for 1/n was between 0.434 and 0.921 at 293 and 323 K. To put it another way, the n value is between 1.08 and 2.30 for all tested temperatures, which indicates that MP was physically and favorably adsorbed onto silica 21,22 .The equilibrium data had an R 2 value of 0.959 to 0.985, which fit the Freundlich expression.…”