Study the efficacy of cyproterone and metformin in modulation of hormonal disturbances in estrogen valerate induced PCOS in female rats

Abstract

Polycystic ovarian syndrome (PCOS) is an endocrine disorder affecting women in child bearing age and is considered the main cause of infertility. This study aims to determine the efficacy of cyproterone 12 mg/ kg and metformin 50 mg/kg as a single oral daily dose for 20 days, in PCOS induced in female rats by estrogen valerate. In untreated group PCOS, the level of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was significantly (P< 0.0001) decrease, while estradiol and testosterone levels were increased significantly (P< 0.0001 and P< 0.001 respectively) in comparison with control group. Both cyproterone and metformin significantly increased LH and FSH levels (P< 0.05) compared to the untreated PCOS group. Both cyproterone and metformin reduced the level of estradiol hormone significantly (P <0.001 and P <0.05, respectively). Cyproterone also decreased the level of testosterone (P <0.0001) compared to the untreated PCOS group, and the testosterone level became less than that recorded in the control group (P <0.05), Metformin also significantly decreased the level of testosterone compared to the untreated PCOS group (P <0.01), but it still more than that in control. According to the results of the current study, we can conclude that cyproterone and metformin showed an efficacy in the treatment of PCO, and can restore the normal hormonal levels and should be considered in the treatment of this disease.