Study the Effect of some Medical Plants in Biofilm Formation and Antibiotic Sensitivity for Klebsiella Pneumoniae

Abstract

Twenty clinical and fecal samples (ten clinical samples from patients attending to Imam Ali Hospital and ten chicken faeces samples collected from local poultry farm in Baghdad city) collected during December 2015, for isolated Klebsiella pneumoniae. All K. pneumoniae isolates were extended-spectrum β-lactamase producers and biofilm formation. The activities of two selected K. pneumoniae isolates for their biofilm formation and susceptibility to antibiotics after treatment with several plants extracts were investigated. The results of water and 60% ethanol extracts for Matricaria chamomile flowers, Alhagi maurorum leafs, Syzygium aromaticum buds (clove) and Arctium minus leafs were showed reduction of biofilm formation and change the ability of antibiotic susceptibility for these two tested K. pneumoniae isolates. The indirect effect of plants extracts on the bacterial growth may be causing indirect effect on the metabolic activity and DNA (chromosome or plasmid) of cells. All tested plant extract contain many antimicrobial and antioxidant component by using GC-mass. Keywords