Study the Effect of Interleukin36 Gamma and AMH in Iraqi Women with PCOS

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and affect approximately (5-10) % of women of reproductive age. Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein, a member of the transforming growth factor-β superfamily, it is secreted exclusively from women by granulose cells of ovarian follicles and it is considered as the precise marker of follicle pool size. AMH has been shown to be a good surrogate marker for polycystic ovary syndrome (PCOS). Interleukins are considered as strong risk markers of inflammation. Interleukin-36 gamma (IL36) also known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the IL36G gene. Serum samples were collected on day 2 of the menstrual cycle. Serum IL36ɣ, FSH and LH concentration were measured by using ELISA. This study aimed to evaluate the association between IL36ɣ and AMH and study the relationship between obesity and AMH of women in the age of reproductive (25-35) yrs. This study included 28 infertile women with PCOS their husbands were apparently normal (hormones and seminal fluid analysis), their aged (25-35) years, and 20 healthy women aged (25-33) years as control. All control women & patients were from outpatients unit of Alkadumia teaching hospital at Baghdad and all the parameters were measured in Sigma Laboratory. Serum IL-36 ɣ elevated in PCOS patients mainly those with high AMH levels. This hormone increased in PCOS patients compared with control. There was a non-significant difference between patients and control to LH and FSH levels. Keywords

Serologic Prevalence of Toxoplasmosis in Women’s Visiting Bahawal Victoria Hospital, Bahawalpur

“…These differences can be reported due to different study backgrounds in terms of varied weather conditions, diverse study population and risk factors like having pets, domestic animals, unhealthy hygienic practice, and eating pattrens (Zemene et al, 2012;Agmas et al, 2015;Abamecha and Awel 2016;Bamba et al, 2017;Frimpong et al, 2017). The study showed significant relation between Toxoplasma gondii and the host suffering from hepatitis, diabetes, nausea, and arthritis which agrees with statement toxoplasmosis affects liver and kidney functions due to increase in the levels of some biochemical parameters in patients group; exhibit severe medical conditions such as pneumonia, hepatitis, blindness and severe brain abnormalities (Al-Fartusie et al, 2012).…”

The Relationship of Staphylococcus aureus Virulancity with Serum Cytokine Levels in Polycystic Ovary Syndrome and Polycystic Ovary Disease

“…The study revealed that 32 (30.47 %) of patients were at the age group of (20-25) years, that 26 (24.76 %) of patients were at the age group of (31-35) years, that 19 (18.09 %) of patients were at the age group of (26-30) years, that 15 (14.28 %) of patients were at the age group of (36-40) years and than that 13 (12.38 %) of patients were at the age group of (41-45) years as shown in table [1]. This result is in agreement with [14] and not agreement with [15], [16] and [17]. The similarities between these studies regarding the same age group because PCOS appeared at menarche and the women became symptomatic later but most women with PCOS are diagnosed when their age between 20-30 years [18].…”

Assessment of Anti-Mullerian Hormone and Anti Ovarian Antibody in the Sera of Patients with Polycystic Ovarian Syndrome in AL-Najaf Al-Ashraf Province

“…The increase of production of AMH prompt the decrease in the sensitivity of follicles to FSH at levels of receptors,which is very necessary for growing of this follicles,it leads to an increase of the numbers of antral follicles on the detriment of their size and the number of small antral follicles size(2-5mm)increases, therefore failure the selection of the dominant follicle and anovulation occur with oligo or amenorrhea (22) .…”