Abstract:Background: The neurodegenerative changes occurring during aging is associated with oxidative stress and inflammatory responses. The role of induction or suppression of heme-oxygenase-1 (HO-l) in these changes still a mystery. Aim: This study was designed to investigate the effect of hemoxygenase-1 (HO-1) induction and suppression on lipopolysaccharide-brain injury in male rats. Materials and Methods: Forty male albino rats were divided into four equal groups: a) control group, received saline at a dose of 10 … Show more
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