Study the Biochemicl Effect of Gum Arabic in Liver Injury and Blood Serum of Mice Induce by Gentamicin

Hepato-toxic risk of gum arabic during adenine-induced renal toxicity prevention

“…Another more recent study of Eyibo et al (2018) concluded that healthy rats administered GA (at doses of 200 mg/kg or 400 mg/kg or 600 mg/kg orally for 2 weeks) had distorted normal body chemistry reflected in body weight reduction, significant ALT and AST increases, lipid profile alterations, and other biochemical levels. On contrary to our results, Gamal el-din et al (2003) and Alubaidy (2013) observed decreased aminotransferases in mice by GA pretreatment (dose of 100 g/l 5 days before acetaminophen hepatotoxic dose) and by GA alone administered to healthy mice (dose of 10 g/kg/day orally for 8 days), respectively. No effect of GA (dose of 0.5 g/kg orally for 2 months) on liver function tests, including aminotransferases, in healthy rats was recorded by Ayaz et al (2017).…”

“…On contrary to our findings, Gamal el-din et al (2003) concluded that pretreatment with GA was able to protect mice against acetaminophen-induced liver damage. Alubaidy (2013) reported GA improved oxidative injure and raised liver regeneration and repair capacity. In addition, Ayaz et al (2017) showed significant decreases in ALT, AST, ALP, and bilirubin along with increases in albumin and total protein to near normal in rats with liver injury induced by trichloroacetate pretreated with GA indicating hepatoprotective effect against subsequent trichloroacetate hepatotoxicity.…”