Study, reconstruction and gross dissection of the atrioventricular conducting system of the dog heart

Baird, Joan A.; Robb, Jane Sands

doi:10.1002/ar.1091080409

Cited by 34 publications

(10 citation statements)

References 18 publications

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“…The general anatomy of the larger branches of the intraventricular portion of the specialized conducting system is similar in the mammalian species (3-7, 30, 31), with some variations from one to another, especially in the degree of intramyocardial penetration. It has been well established that much of the length of the specialized conducting system, and certainly the more proximal portion, is anatomically separated from surrounding muscle by connective tissue sheaths (3,(5)(6)(7)31). Moreover, Abramson and Margolin (3) did not observe intramyocardial Purkinje fibers penetrating the upper septum or the upper portions of the papillary muscles.…”

Section: Circulation Research Vol XXX February 1972mentioning

confidence: 99%

“…Our present knowledge of these relationships has been developed by the early physiologist-clinicians such as Lewis (1,2), the later anatomists and pathologists (3)(4)(5)(6)(7)(8), and the modern physiologists and clinicians (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). A number of different techniques, each with its own values and limitations, have been used to study these problems.…”

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confidence: 99%

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Physiology of Canine Intraventricular Conduction and Endocardial Excitation

Myerburg

Nilsson

Gelband

1972

Circulation Research

181

111

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The sequence of conduction through the intraventricular conducting system and endocardial muscle was studied by microelectrode mapping of large areas of isolated canine ventricular tissue. We found that most of the endocardium of the right ventricular free wall is activated simultaneously whereas the left endocardial muscle is activated in an apex-to-base sequence. Right septal activation is from apex to base, and the left septum is activated first at the junction of the middle and lower thirds of the septum and then as a bidirectional wave front toward the apex and the base. These right-left differences occur because the sites of impulse input into muscle on the right encompass the entire free wall, base of the papillary muscle, and the lowermost septum, and on the left are primarily limited to the lower ventricular cavity, lower septum, and bases of the papillary muscles. These patterns of left ventricular excitation relate to the presence of a functionally continuous ring of conducting tissue formed by a merger of the major divisions of the left bundle branch on the upper left ventricular free wall. The "ring" itself is electrophysiologically isolated from muscle, but connects to a network of subendocardial conducting tissue extending to the apex and having input to muscle only in its lower portions. KEY WORDSAV conduction papillary muscles bundle branches conducting system Purkinje fibers cardiac electrophysiology septal activation myocardial activation ventricular muscle• The relationship between the anatomy of the intraventricular portion of the AV conducting system and the physiology of AV conduction and ventricular excitation is pertinent to our understanding of major areas of cardiac electrophysiology. The nature and location of impulse input from the intraventricular conducting system into the ventricular myocardium, the physiological interactions between conducting tissue and ordinary muscle cells, and the sequence of activation of the endocar-Downloaded from curred, but the apex-to-base muscle activation persisted. White numbers on black background = conducting cells; black numbers on white background = muscle cells.

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Section: Circulation Research Vol XXX February 1972mentioning

confidence: 99%

mentioning

confidence: 99%

Physiology of Canine Intraventricular Conduction and Endocardial Excitation

Myerburg

Nilsson

Gelband

1972

Circulation Research

181

111

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“…Importantly, three-dimensional reconstructions are required to visualize continuities between fibers of the AVN and contiguous myocardium in transverse sections (Truex and Smythe, 1967). While only a few studies have been reported in which reconstructions were made (Baird and Robb, 1950;James, 1961;Truex and Smythe, 1967;Anderson et al, 19751, there were major differences between them, as follows. Baird and Robb (19501, in a study of the dog heart which was based on dissections and histologic sections, found that a major blood vessel entered the substance of the AVN.…”

mentioning

confidence: 99%

Atrioventricular node and input pathways: A correlated gross anatomical and histological study of the canine atrioventricular junctional region

Racker¹

1989

Anat. Rec.

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To determine the architecture of the atrioventricular (AV) junctional region, structures in atrial preparations were correlated to those in serial sections made either parallel or perpendicular to the long axis of the AV node (AVN)/AV bundle complex. The results demonstrated the following for the first time: 1) A right medial atrial wall (MAW) extends anteriorly from the interatrial septum, superior to the interventricular septum (IVS). 2) An atrial interventricular septum (A-IVS) groove is located between the base of the MAW and the crest of the IVS. 3) Three atrionodal bundles converge to form a proximal AV bundle (PAVB), which in turn is contiguous with the AVN. The atrionodal bundles are associated with the MAW or the superomedial and inferolateral margins of the coronory sinus. Terminal portions of the atrionodal bundles and the PAVB reside within the A-IVS groove. The AV bundle was termed distal (DAVB) to avoid confusion. 4) The location of the AVN/DAVB complex topographically is deep to the apex of the septal cusp of the tricuspid valve subjacent to the MAW. Intracardially, the AVN/DAVB complex is within the central fibrous body. Significantly, this study resulted in the first unequivocal demonstration of discrete bundles of myocardial fibers associated with the atrial end of the AV node. Moreover, it appears likely that the atrionodal AV bundles are continuous with the sinoatrial nodal extensions, thereby forming internodal tracts.

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“…Since the early days, HIS (1893), TAWARA (1906), COHN (1909), HOLL (1912), LEWIS (1921), NONIDEZ (1943), BAIRD and ROBB (1950), TRUEX (1961), JAMES (1964) and others have histologically studied the atrioventricular system of the heart. Present investigation reveals that canine atrioventricular system has similar morphological feature to the other mammals.…”

Section: Discussionmentioning

confidence: 99%

“…Although his coworkers (1940-1952) postulated on the basis of their observations that conduction system of the tissue, but through the intracardiac nervous tissue, this neurogenic theory was denied by WALLS (1947), TRUEX and COPENHAVER (1947), COPENHAVER and TRUEX (1952), BAIRD and ROBB (1950), KUGLER and PARKIN (1956) and others. Today, myogenic theory of the conduction is widely supported by morphologists and physiologists.…”

Section: Accordingmentioning

confidence: 99%

Morphological and Histochemical Studies on the Cardiac Conduction System of the Dog

Hara

1967

Arch. Histol. Jap., Arch. Histol. Jpn

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Study, reconstruction and gross dissection of the atrioventricular conducting system of the dog heart

Cited by 34 publications

References 18 publications

Physiology of Canine Intraventricular Conduction and Endocardial Excitation

Physiology of Canine Intraventricular Conduction and Endocardial Excitation

Atrioventricular node and input pathways: A correlated gross anatomical and histological study of the canine atrioventricular junctional region

Morphological and Histochemical Studies on the Cardiac Conduction System of the Dog

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