Study protocol to investigate the correlation between Tourette syndrome and allergy in children and adolescents

Abstract

Objective Noting that the usefulness of cases diagnosed in administrative registers is dependent on diagnostic validity, in this study, we aim to elucidate the correlation between Tourette syndrome and allergy in children and adolescents, specifically with regard to incidence of asthma, allergic rhinitis, allergic conjunctivitis, and atopic dermatitis. Methods Based on a set of inclusion and exclusion criteria, we intend to enroll 200 children and adolescents aged 18 years and younger, accompanied by their parents, for a duration of 2 years. We will administer an anonymous questionnaire in a case–control study. We will use the chi-squared test to evaluate differences between cases and controls. Results According to the European Review for Medical and Pharmacological Sciences, the proportion of allergic diseases expected in patients with Tourette syndrome is 53.1% (17/32) and 22.9% (8/35) in the controls. Setting the type 1 error to 0.05 and the power to 0.8, we will ensure a 1:2 case-to-control ratio. Conclusions This study protocol describes our analysis of anonymous questionnaire responses. Comorbidity rates, environmental factors, and genetic factors for various allergens, allergies, and other neuropsychiatric disorders will be studied.

Management of allergic rhinitis improves clinical outcomes of difficult-to-treat tic disorders or attention-deficit/hyperactivity disorders

“…Inclusion criteria: 1) previous diagnosis of TD/ADHD in the psychiatry specialist hospital or children’s hospital. The diagnostic criteria for TD/ADHD by pediatric psychiatrists were clinically assessed in accordance with the American Mental Illnesses Diagnostic and Statistical Manual 5 th Edition (DSM-5) or Chinese Mental Disorders and Diagnostic Criteria 3rd Edition (CCMD-3) [ 14 , 15 , 16 , 17 ]. 2) AR diagnosis according to the Guidelines for the Diagnosis and Treatment of Allergic Rhinitis [ 11 , 18 ].…”