Study protocol of the multi-centre, randomised controlled trial of the Frankfurt Early Intervention Programme A-FFIP versus early intervention as usual for toddlers and preschool children with Autism Spectrum Disorder (A-FFIP study)

Kitzerow, Janina; Hackbusch, Matthes; Jensen, Katrin; Kieser, Meinhard; Noterdaeme, Michele; Fröhlich, Ulrike; Taurines, Regina; Geißler, Julia; Wolff, Nicole; Roessner, Veit; Bast, Nico; Teufel, Karoline; Kim, Ziyon; Freitag, Christine M.

doi:10.1186/s13063-019-3881-7

Cited by 8 publications

(6 citation statements)

References 78 publications

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“…The recruitment strategy included contacting families that were on the wait list for therapy at the Frankfurt Autism Intervention and Research Center of Excellence, local advertisement in kindergartens, social media and health system institutions. The assessment of ASD participants was part of the baseline measurement of a randomized controlled trial (Kitzerow et al, 2020) that received ethical coverage from the local ethics committee (10/18). TD assessments received another ethical coverage (361/18).…”

Section: Methodsmentioning

confidence: 99%

“…Exclusion criteria of ASD participants were based on the study protocol by Kitzerow et al (2020). TD participants were excluded if they showed at least one scale of the German version of the Child Behavior Checklist 1 ½–5 (Achenbach, 2013) in clinical ranges ( T > 65) or a T ‐score >75 in the German version of the Social Responsiveness Scale (SRS; Bölte et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

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Pupillometric measures of altered stimulus‐evoked locus coeruleus‐norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder

2022

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Attenuated social attention has been described as a reduced preference for social compared to geometric motion in preschoolers with autism spectrum disorder (ASD). The locus coeruleus-norpinephrine (LC-NE) system modulates sensory reactivity and is a promising underlying mechanism. LC-NE activity is indexed by a stimulus-evoked pupillary response (SEPR) and partially by a luminanceadaptation pupillary response (LAPR), which were both shown to be aberrant in ASD. We examined whether SEPR and LAPR explain an attenuated social motion preference. We applied pupillometry via video-based eye tracking in young children (18-65 months) with ASD (n = 57) and typically developing (TD) children (n = 39) during a preferential looking paradigm of competing social and geometric motion and a changing light condition paradigm. We found an attenuated social motion preference in the ASD compared to the TD group. This was accompanied by atypical pupillometry showing a smaller SEPR to social motion, a larger SEPR to geometric motion and a reduced LAPR to a dark screen. SEPR but not LAPR explained the group difference in social motion preference. An ASD diagnosis was statistically predicted by the social motion preference, while this effect was mediated by the inclusion of SEPR to geometric and social motion. Our findings suggest a decreased sensory reactivity to social and increased reactivity to non-social motion in ASD, which may concurrently contribute to an attenuated social attention. The LC-NE system is supported as a promising underlying mechanism of altered social attention in young children with ASD, while the specificity of findings remains to be addressed.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Pupillometric measures of altered stimulus‐evoked locus coeruleus‐norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder

2022

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“…Early intervention has a significant impact on ASD patient’s progress and improvement [ 24 , 25 ]. Although The American Academy of Pediatrics recommended routine screening of ASD for children aged from 18 months to 24 months, few centres or even countries follow this screening routine [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

National Profile of Caregivers’ Perspectives on Autism Spectrum Disorder Screening and Care in Primary Health Care: The Need for Autism Medical Home

Al-Mazidi

Al-Ayadhi

2021

IJERPH

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Although autism spectrum disorder (ASD) is a common developmental disorder, primary healthcare providers show a deficit in providing early diagnosis. To understand parents’ experience and perspective in the diagnosis and intervention process of their children, a survey was deployed through social media to parents’ with at least one child diagnosed with ASD. The survey included parents experience, satisfaction and perception in the diagnosis process and services provided for their children, stigma and type of support received. A total of 223 participants were enrolled. Although 62% of ASD patients were diagnosed by three years old, most diagnoses (66%) were non-physician initiated. Additionally, 40.8% of the parents reported that the services required for their child are available in their area of residence, but only 7.9% were satisfied with these services. Parents who received psychological support (9.9%) started early intervention, and their children have a better prognosis (p ≤ 0.005). Stigmatized parents were more likely to delay intervention (p ≤ 0.005). Parents’ perception is to have qualified healthcare and educational professionals experienced in ASD. Our findings suggest that a specialized family-centred medical home for ASD patients would significantly benefit ASD patients, increase parents’ satisfaction, reduce parents’ stress, and ease their children’s transition to adolescents.

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“…Within this manuscript, we use an initial selection of a subset of datasets selected for inclusion in R2D2-MH. These datasets included the EU-AIMS Longitudinal European Autism Project (LEAP) 57 , The Preschool Brain Imaging and Behaviour Project (PIP) https://www.aims-2-trials.eu/pip/, Evaluation of Magnetic Resonance Imaging to Predict Neurodevelopmental Impairment in Preterm Infants (ePRIME) 63 , the SOSTA-net Randomized Controlled Trial (RCT) 64 , the ASD-speci c Frankfurt Early Intervention Programme for ASD RCT (A-FFIP) 65 , the Neurobiology and Treatment of Adolescent Female Conduct Disorder (FemNat-CD) 66 and the developing Human Connectome Project (dHCP) 67 . The datasets cover a broad range of cohorts in neurodevelopmental conditions and mental health, including diagnoses of autism, ADHD, intellectual disability, developmental delay, epilepsy, and conduct disorders, with ages ranging from infants born preterm to adults.…”

Section: Data Sourcesmentioning

confidence: 99%

Harmonizing Big Data in Mental Health Research: A Proof-of-Principle in the R2D2-MH Consortium Using the International Classification of Functioning (ICF)

Black,

Buitelaar,

Charman

et al. 2023

Preprint

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Big data approaches in mental health research hold great promise to advance research and support for neurologically diverse populations. The Risk, Resilience and Developmental Diversity in Mental Health (R2D2-MH) project moves from risk-focused studies toward understanding and promoting resilience, and from a diagnosis-based approach to a developmental diversity approach that defines well-being across the lifespan. Here, we present a proof-of-principle in R2D2-MH demonstrating that the International Classification of Functioning (ICF) can facilitate content harmonization in mental health research to generate big data compatible with several contemporary approaches in psychiatry. Transforming data through the ICF classification system allowed data collected with a wide range of instruments across modalities and diverse populations to be harmonized under the widely accepted WHO framework. Data harmonized using the ICF provides novel opportunities for large-scale data analyses that may be more capable of capturing diversity, aligning with more transdiagnostic and neurodiversity-affirmative ways of understanding data.

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Study protocol of the multi-centre, randomised controlled trial of the Frankfurt Early Intervention Programme A-FFIP versus early intervention as usual for toddlers and preschool children with Autism Spectrum Disorder (A-FFIP study)

Cited by 8 publications

References 78 publications

Pupillometric measures of altered stimulus‐evoked locus coeruleus‐norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder

Pupillometric measures of altered stimulus‐evoked locus coeruleus‐norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder

National Profile of Caregivers’ Perspectives on Autism Spectrum Disorder Screening and Care in Primary Health Care: The Need for Autism Medical Home

Harmonizing Big Data in Mental Health Research: A Proof-of-Principle in the R2D2-MH Consortium Using the International Classification of Functioning (ICF)

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