Study protocol for a revised randomized trial: Remotely delivered Tai Chi and wellness for Gulf War illness

Niles, Barbara L.; Grossman, Stephanie; McQuade, Maria; Grossman, Dan; Kaiser, Anica Pless; Muccio, Brian; Warner, Ben; Wang, Chenchen; Mori, DeAnna L.

doi:10.1016/j.cct.2022.107045

Cited by 4 publications

(1 citation statement)

References 53 publications

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“…Further, antioxidant co-enzyme Q10 (CoQ10), a low-risk therapeutic agent, Bacopa monnieri, anti-inflammatory flavonoid concord grade juice (CGJ), and mifepristone therapies beyond Phase II clinical trials for GWI patients have shown some progresses for therapeutic interventions in addition to cognitive and behavioral therapies in place [ 115 , 116 , 117 ]. In addition, other randomized trials using Tai Chi, problem-solving treatment (PST), yoga and cognitive behavioral therapy (CBT) have been carried out to investigate their efficacies in cognitive performance of GWI patients [ 118 , 119 , 120 , 121 , 122 ]. These encouraging reports show that we need further investigations to have effective GWI therapies in practice.…”

Section: Gulf War Illness (Gwi)mentioning

confidence: 99%

Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders

Cohen,

Mathew,

Dourvetakis

et al. 2024

Cells

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Neuroinflammatory and neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood–brain barrier and tight junction proteins. Activation of glial cells and immune cells leads to the release of many inflammatory and neurotoxic molecules that cause neuroinflammation and neurodegeneration. Gulf War Illness (GWI) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are chronic disorders that are also associated with neuroimmune dysfunctions. Currently, there are no effective disease-modifying therapeutic options available for these diseases. Human induced pluripotent stem cell (iPSC)-derived neurons, astrocytes, microglia, endothelial cells and pericytes are currently used for many disease models for drug discovery. This review highlights certain recent trends in neuroinflammatory responses and iPSC-derived brain cell applications in neuroinflammatory disorders.

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Section: Gulf War Illness (Gwi)mentioning

confidence: 99%

Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders

Cohen,

Mathew,

Dourvetakis

et al. 2024

Cells

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An interpretable composite CNN and GRU for fine-grained martial arts motion modeling using big data analytics and machine learning

Chen

2024

Soft Comput

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Addressing gaps in pain research from an integrated whole person perspective

Langevin

2024

Pain

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While our understanding of pain is rapidly growing, some areas of pain research are lagging behind. This article discusses two current and inter-related gaps in knowledge that are in need of addressing: first, the connections between “brain” and “body” components of pain; and second, the process of endogenous pain resolution. Historical reasons for these research gaps are discussed and solutions are outlined based on an integrative, whole person research approach. These include comprehensive mapping of the mechanosensory and nociceptive innervation of deep tissues; developing objective, non-invasive measurements to quantify the metabolic, structural and mechanical components of the peripheral tissue environment; integrating our understanding of pain pathophysiology, across whole organs and whole body, as well as across bio-psycho-social domains; and understanding the interplay of nervous system and peripheral tissue mechanisms that promote the endogenous resolution of pain and prevent its acute-to-chronic transition. Current NIH-led efforts in these areas are outlined, including several studies within the NIH HEAL (or Help End Addition Long Term) initiative and the National Center for Complementary and Integrative Health's strategic priorities in whole person research.

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Study protocol for a revised randomized trial: Remotely delivered Tai Chi and wellness for Gulf War illness

Cited by 4 publications

References 53 publications

Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders

Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders

An interpretable composite CNN and GRU for fine-grained martial arts motion modeling using big data analytics and machine learning

Addressing gaps in pain research from an integrated whole person perspective

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