Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study

Takeuchi, Kenji; Naito, Mariko; Kawai, Shinya; Tsukamoto, Mineko; Kadomatsu, Yuka; Kubo, Yoko; Okada, Rieko; Nagayoshi, Mako; Tamura, Takashi; Hishida, Asahi; Nakatochi, Masahiro; Sasakabe, Tae; Hashimoto, Shuji; Eguchi, Hidetaka; Momozawa, Yukihide; Ikezaki, Hiroaki; Murata, Masayuki; Furusyo, Norihiro; Tanaka, Keitaro; Hara, Megumi; Nishida, Yuichiro; Matsuo, Keitaro; Ito, Hidemi; Oze, Isao; Mikami, Haruo; Nakamura, Yohko; Kusakabe, Miho; Takezaki, Toshiro; Ibusuki, Rie; Shimoshikiryo, Ippei; Suzuki, Sadao; Nishiyama, Takeshi; Watanabe, Miki; Koyama, Teruhide; Ozaki, Etsuko; Watanabe, Ichiro; Kuriki, Kiyonori; Kita, Yoshikuni; Ueshima, Hirotsugu; Matsui, Kenji; Arisawa, Kokichi; Uemura, Hirokazu; Katsuura‐Kamano, Sakurako; Nakamura, Shotaro; Narimatsu, Hiroto; Hamajima, Nobuyuki; Tanaka, Hideo; Wakai, Kenji

doi:10.2188/jea.je20200147

Cited by 52 publications

(48 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Participants. The Japan Multi-Institutional Collaborative Cohort Study, was launched in 2005 to investigate gene-environmental interactions in lifestyle-related diseases 36,37 . This study included individuals who were enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study second survey in the Kyoto area from 2013 to 2017.…”

Section: Methodsmentioning

confidence: 99%

Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study

Koyama

Kuriyama

Suzuki

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

We investigated the potential of mid-regional pro-adrenomedullin (MR-proADM) for use as a novel biomarker for arterial stiffness as the criterion for vascular failure and cardiometabolic disease (obesity, hypertension, dyslipidemia, diabetes, and metabolic syndrome) compared with high-sensitivity C-reactive protein (hsCRP). Overall, 2169 individuals (702 men and 1467 women) were enrolled. Multiple regression analysis was performed to assess the association of MR-proADM and hsCRP with brachial-ankle pulse wave velocity (baPWV), adjusting for other variables. The diagnostic performance (accuracy) of MR-proADM with regard to the index of vascular failure was tested with the help of receiver operating characteristic curve analysis in the models. MR-proADM was significantly higher in participants with vascular failure, as defined by baPWV and/or its risk factors (obesity, hypertension, dyslipidemia, diabetes, and metabolic syndrome), than in control groups. Independent of cardiovascular risk factors (age, drinking, smoking, body mass index, systolic blood pressure, lipid and glycol metabolism), MR-proADM was significantly associated with baPWV, and MR-proADM showed higher areas under the curve of baPWV than hsCRP showed. MR-proADM is more suitable for the diagnosis of higher arterial stiffness as the criterion for vascular failure than hsCRP. Because vascular assessment is important to mitigate the most significant modifiable cardiovascular risk factors, MR-proADM may be useful as a novel biomarker on routine blood examination.

show abstract

Section: Methodsmentioning

confidence: 99%

Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study

Koyama

Kuriyama

Suzuki

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, we have adopted the lifestyle questionnaire, which was established in J-MICC study. 46 Besides the current study, The Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT), 47 and Yamagata Molecular Epidemiological Cohort Study 48 use the same or similar questionnaire. The J-MICC and JPHC-NEXT have conducted a validity study by examining all questionnaires for integrated analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The J-MICC and JPHC-NEXT have conducted a validity study by examining all questionnaires for integrated analysis. 46 Therefore, we believe that the validity and reliability of the questionnaire used in the current study have been assured by many series of epidemiologic studies. Fourth, weight change time courses were not examined.…”

mentioning

confidence: 85%

Weight Gain After 20 Years of Age is Associated with Unfavorable Lifestyle and Increased Prevalence of Metabolic Disorders

Takebe¹,

Tanno²,

Ohmomo³

et al. 2021

DMSO

View full text Add to dashboard Cite

Purpose It is unclear what kind of modifiable lifestyle factors are associated with long-time weight gain in adulthood. To clarify the lifestyle behavior related to body weight gain since the age of 20 years, we explored the lifestyle risk factor, independently associated with excessive weight gain after 20 years of age as compared to those in subjects with a stable weight, with matching of age, gender, and the current body mass index (BMI). Patients and Methods From baseline data of a general population-based cohort study, we designed a cross-sectional analysis collecting individual data of medical health check-ups and a questionnaire related to lifestyle, including amount of sleep, frequency of eating breakfast, average times per day engaged in walking and sitting in the prior year, and smoking habits. These data were compared between the subjects with weight gain ≥10kg (n=3601) and <10kg (n=3601) after age 20, matched by a propensity score model which included current BMI, age and gender. We used multivariable logistic regressions to assess the lifestyle factor’s association with high weight gain. Results Participants who gained ≥10 kg were significantly more likely to sleep <5 hours or ≥9 hours per night, skip breakfast, engage in walking <1 hour per day, and sit ≥5 hours per day than those who gained <10kg. Multivariable logistic regressions analyses showed that, with adjusting for potential confounder, the lifestyles with the positive association with high weight gain were skipping breakfast (OR 1.252; 95% CI 1.053–1.489, vs regularly), long sleeping duration (9 hours/day≤ OR 1.613; 95% CI 1.018–2.557 vs 5≤-<7 hours/day), and former smoker (OR 1.163; 95% CI 1.008–1.343 vs never smoker), while walking duration was negatively associated with high weight gain. Furthermore, despite similar current BMI, participants with weight gain ≥10kg had significantly higher values for waist circumference, blood pressure, HbA1c, LDL-C, triglycerides, and hepatic enzyme levels than those with weight gain <10kg. Similarly, the prevalence rates of hypertension, dyslipidemia, metabolic syndrome (MetS), and former smoker were higher in the participants with weight gain ≥10kg. Conclusion Major weight gain after 20 years of age was associated with unfavorable lifestyle factors and greater waist circumference, possibly leading to elevated risk for MetS and other non-communicable diseases. These findings highlight the importance of maintaining both weight at age 20 and a favorable lifestyle throughout adulthood.

show abstract

“…The details of the J-MICC Study have been described previously elsewhere and the latest information is available on its website (http://www.jmicc.com). 21,22 The selection process of participants is shown in Supplementary Figure 1. From the genotyped 14,539 subjects, 26 samples with inconsistent sex information between questionnaire and an estimate from genotype were excluded.…”

Section: Study Subjectsmentioning

confidence: 99%

Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study

Fujii

Hishida

Nishiyama

et al. 2022

Journal of Epidemiology

Self Cite

View full text Add to dashboard Cite

Background: Inflammation is thought to be a risk factor for kidney disease. However, discussion is controversial whether inflammatory status is either a cause or an outcome of chronic kidney disease. We aimed to investigate the causal relationship between highsensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) using mendelian randomization (MR) approaches.Methods: A total of 10,521 participants of the Japan Multi-institutional Collaborative Cohort Study was analyzed in this study. We used two-sample MR approaches (the inversevariance weighted (IVW), the weighted median (WM), and the MR-Egger method) to estimate the effect of genetically determined hs-CRP on kidney function. We selected four and three hs-CRP associated single nucleotide polymorphisms (SNPs) as two instrumental variables (IV): IVCRP and IVAsian, based on SNPs previously identified in European and Asian populations. IVCRP and IVAsian explained 3.4% and 3.9% of the variation in hs-CRP, respectively.Results: Using the IVCRP, genetically determined hs-CRP was not significantly associated with eGFR in the IVW and the WM methods (estimate per 1 unit increase in ln(hs-CRP),

show abstract

Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study

Cited by 52 publications

References 21 publications

Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study

Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study

Weight Gain After 20 Years of Age is Associated with Unfavorable Lifestyle and Increased Prevalence of Metabolic Disorders

Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study

Contact Info

Product

Resources

About