Abstract:Aim. To select scFv which have an ability to neutralize diphtheria toxin. Methods. Flow-cytometry was used to study the ability of specific scFv to block the binding of a labeled receptor binding fragment of toxin with a surface of sensitive to toxin cells. Results. Four scFv with toxin-neutralization properties were selected. Conclusions. The obtained scFv could be considered as promising candidates for antitoxic antidiphtheria drugs of new generation
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