Study on tinnitus-related electroencephalogram microstates in patients with vestibular schwannomas

Zhang, Chi; Wang, Xiaoguang; Ding, Zhiwei; Zhou, Hanwen; Liu, Peng; Xue, Xin-Miao; Wang, Li; Jiang, Yuke; Chen, Jiyue; Shen, Wei-Dong; Yang, Shi‐Ming; Wang, Fangyuan

doi:10.3389/fnins.2023.1159019

Cited by 1 publication

(1 citation statement)

References 54 publications

(67 reference statements)

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“…Zhang et al studied on the patients with vestibular schwannoma (VS) and tinnitus. They found that compared to the patients with VS and no tinnitus, the EEG microstate C of the patients with VS and tinnitus showed an increment of frequency, and the score of tinnitus handicap inventory (THI) was negatively correlated with the duration of Microstate A and positively correlated with the frequency of Microstate C [25]. De Ridder and Vanneste suggested that the pain and tinnitus patients were in a specific Microstate for half of the time [26][27].…”

Section: Introductionmentioning

confidence: 99%

Objective Neurophysiological Indices for the Assessment of Chronic Tinnitus Based on EEG Microstate Parameters

Wang,

Zeng,

et al. 2024

IEEE Trans. Neural Syst. Rehabil. Eng.

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Chronic tinnitus has a high prevalence but lacks effective treatment, precise diagnostic, or therapeutic standards. Its onset and treatment mechanisms remain unclear, and there is a shortage of objective assessment methods. We aim to identify abnormal neural activity and reorganization in tinnitus patients and reveal potential neurophysiological markers for objectively evaluating tinnitus. By way of analyzing EEG microstates, comparing metrics under three resting states (OE, CE, and OECEm) between tinnitus sufferers and controls, and correlating them with tinnitus symptoms. This study reflected specific changes in the EEG microstates of tinnitus patients across multiple resting states, as well as inconsistent correlations with tinnitus symptoms. Microstate parameters were significantly different when patients were in OE and CE states. Specifically, the occurrence of Microstate A and the transition probabilities (TP) from other Microstates to A increased significantly, particularly in the CE state (32-37%, p≤0.05); and both correlated positively with the tinnitus intensity. Nevertheless, under the OECEm state, increases were mainly observed in the duration, coverage, and occurrence of Microstate B (15-47%, p<0.05), which negatively correlated with intensity (R<-0.513, p<0.05). Additionally, TPx between Microstates C and D were significantly reduced and positively correlated with HDAS levels (R>0.548, p<0.05). Furthermore, parameters of Microstate D also correlated with THI grades (R<-0.576, p<0.05). The findings of this study could offer compelling evidence for central neural reorganization associated with chronic tinnitus. EEG microstate parameters that correlate with tinnitus symptoms could serve as neurophysiological markers, contributing to future research on the objective assessment of tinnitus.

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Section: Introductionmentioning

confidence: 99%