Study on the Treatment of Acute Thallium Poisoning

Long‐term misdiagnosis and neurologic outcomes of thallium poisoning: A case report and literature review

“…Nine articles including 98 cases with thallium poisoning were retrieved in our literature review (Table 2) (Afshari et al., 2012; Al Hammouri et al., 2011; Desenclos et al., 1992; Di Candia et al., 2020; Li et al, 2014; Lin et al., 2019; Meggs et al., 1994; Sun et al., 2012; Zhang et al., 2014). The median age of the patients was 30 years (range 2–73 years).…”

Thallium toxicity due to audultered infusion with thallium sulfate in eight members belonging to the same family nucleus: Autopsy findings and ICP-MS analysis (inductively coupled plasma mass spectrometry) in a triple homicide

“…Acute intoxication from thallium (the lethal dose in men is estimated to be between 8 and 12 mg/kg; the lethal plasmatic concentration is considered to be between 0.5 and 11 mcg/mL) is an exceptional and often rare condition [9] and is one of the most rare and complex situations studied [10]: in the biological processes, thallium acts in a way similar to potassium but with an affinity 10 times higher, replacing this latter substance in a series of enzymatic complexes, especially mitochondrial, that need this substance as an activator and ending up being damaged [11]. In fact, the immediate administration of thallium, via any way of administration, generates lethal effects caused by a complete upsetting of important processes with a mechanism that has not yet been clarified [12].…”

Hair Loss: Evidence to Thallium Poisoning

“…In addition, because it has a far better safety profile than other proposed therapies, Prussian blue should be considered as the priority of the drug in managing acute thallium poisoning [ 13 ]. At the same time, the patient may take magnesium sulfate orally to promote excretion of thallium [ 14 ]. Forced diuresis with potassium loading was previously recommended to increase the renal clearance of thallium [ 14 ].…”

“…At the same time, the patient may take magnesium sulfate orally to promote excretion of thallium [ 14 ]. Forced diuresis with potassium loading was previously recommended to increase the renal clearance of thallium [ 14 ]. Due to the small molecular size and low binding affinity to protein, thallium is thought to be dialyzable.…”