Study on the skin status of mid‐pregnancy women based on lipidomics

Chen, Feng; Huang, Dianchao

doi:10.1111/jocd.13866

Cited by 4 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A sample can be collected easily and non-invasively via a gentle swab of skin areas rich in sebum (for example the face, neck or back). Characteristic features have previously been identified from sebum for a limited number of conditions such as Parkinson's Disease and Type 1 Diabetes Mellitus; [ 10 , 11 , 12 ] sebum changes have also been reported in pregnancy [13] . In addition, whilst the mechanisms for the role of sebum in barrier function are not fully described, sebum lipids provide this function directly and also through commensal bacteria interactions; lipid dysregulation would have implications for skin health [14] .…”

Section: Introductionmentioning

confidence: 99%

Changes to the sebum lipidome upon COVID-19 infection observed via rapid sampling from the skin

et al. 2021

View full text Add to dashboard Cite

Background The COVID-19 pandemic has led to an unprecedented demand for testing - for diagnosis and prognosis - as well as for investigation into the impact of the disease on the host metabolism. Sebum sampling has the potential to support both needs by looking at what the virus does to us, rather than looking for the virus itself. Methods In this pilot study, sebum samples were collected from 67 hospitalised patients (30 COVID-19 positive and 37 COVID-19 negative) by gauze swab. Lipidomics analysis was carried out using liquid chromatography mass spectrometry, identifying 998 reproducible features. Univariate and multivariate statistical analyses were applied to the resulting feature set. Findings Lipid levels were depressed in COVID-19 positive participants, indicative of dyslipidemia; p -values of 0·022 and 0·015 were obtained for triglycerides and ceramides respectively, with effect sizes of 0·44 and 0·57. Partial Least Squares-Discriminant Analysis showed separation of COVID-19 positive and negative participants with sensitivity of 57% and specificity of 68%, improving to 79% and 83% respectively when controlled for confounding comorbidities. Interpretation COVID-19 dysregulates many areas of metabolism; in this work we show that the skin lipidome can be added to the list. Given that samples can be provided quickly and painlessly, we conclude that sebum is worthy of future consideration for clinical sampling. Funding The authors acknowledge funding from the EPSRC Impact Acceleration Account for sample collection and processing, as well as EPSRC Fellowship Funding EP/R031118/1, the University of Surrey and BBSRC BB/T002212/1. Mass Spectrometry was funded under EP/P001440/1 .

show abstract

Section: Introductionmentioning

confidence: 99%

Changes to the sebum lipidome upon COVID-19 infection observed via rapid sampling from the skin

et al. 2021

View full text Add to dashboard Cite

show abstract

“…We studied the SSL of 99 young women (Asians, 53 women in mid‐pregnancy and 46 non‐pregnant women; age 18–35 years) and found that the TLs content of women in the middle pregnancy was significantly lower than non‐pregnant women. The results of screening important different lipids showed that the FAs, TG and diglyceride (DG) contents of women in the middle pregnancy decreased significantly, and the contents of GPs and Cers were significantly increased 16,17 …”

Section: Lipidomics Indicated Potential Consistency In Lipidome Chang...mentioning

confidence: 99%

“…The results of screening important different lipids showed that the FAs, TG and diglyceride (DG) contents of women in the middle pregnancy decreased significantly, and the contents of GPs and Cers were significantly increased. 16,17…”

Section: Changes Of Ssl In the Middle Of Pregnancymentioning

confidence: 99%

Lipidomics demonstrates the association of sex hormones with sebum

Chen

et al. 2021

J of Cosmetic Dermatology

Self Cite

View full text Add to dashboard Cite

Sex hormones are divided into androgen and estrogen, which can directly or indirectly regulate the activity of sebaceous glands. Among them, testosterone (T) and dihydrotestosterone (DHT) are most biologically active in androgens. After binding to androgen receptor in the basal layer of sebocytes, the excessive increment and sebum production of sebum cells are promoted by synergistic action with PPAR ligands. 1,2 However, estrogen does not directly affect the activity of sebocytes, but can achieve indirect effects by inhibiting androgen regulation of sebocytes. 3 For example, progesterone can block androgen receptors and inhibit the activity of free androgen in vivo. Estradiol can reduce the level of androgens with bio-active by up-regulating the level of sex hormone-binding globulin. 4 Therefore, sex hormones do have a crucial effect on sebocytes. Importantly, we also supported this by qualitative analysis in the changes of skin surface lipid (SSL) content and composition in people with different sex hormone levels through lipidomics.Lipidomics can conduct a comprehensive and systematic analysis of lipids, reveal the relationship between lipids and cells, organs, and bodies in physiology and pathology by identifying the structure and function of lipids. 5 In the past few years, we used lipidomics (Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight-Mass Spectrometer, UPLC-QTOF-MS) to analyze the important role of lipids in different skin conditions. [6][7][8][9][10] Including acne vulgaris, sensitive muscles, etc., we found significant differences in SSL in different skin conditions. [10][11][12] Importantly, when we studied the SSL of young men and women and middle-pregnancy women (without obvious skin diseases), we stumbled upon potential consistency in their lipid changes. Through literature research and data analysis, we found that this phenomenon may be related to the level of sex hormones in the body. 13 The regulation of sebocytes by sex hormones leads to the change of sebum. 14 Therefore, this paper focuses on sex hormones and sebum, in order to reveal the important association of sex hormones on sebum.

show abstract