Study on the Secondary Metabolites of the Endophytic Fungus Aspergillus terreus HQ100X-1 in Scutellaria formosana

Abstract

a,b ( a 海南师范大学化学与化工学院 热带药用资源化学教育部重点实验室 海口 571158) ( b 海南师范大学化学与化工学院 热带药用植物化学海南省重点实验室 海口 571158) ( c 海南科技职业大学 药食同源植物资源海南省重点实验室 海口 571126) 摘要 从蓝花黄芩内生真菌土曲霉(Aspergillus terreus) HQ100X-1 发酵产物中分离得到 2 个新化合物[terrustone (1)和 asperteretone G (2)], 10 个已知化合物(3～12), terrustone (1)为具有 4 个连续手性中心的三羟基环戊酮类化合物, 它们的 结构以及绝对构型是通过 1D/2D NMR 结合电子圆二色谱(ECD)计算来确定. 抗菌实验表明, 化合物 rbrolide R (4)对金 黄色葡萄球菌有一定的抑菌活性, 其最低抑菌浓度(MIC)值为 2.5 μg/mL.

Four Undescribed Pyranones from the Scutellaria formosana-Derived Endophytic Fungi Ascomycota sp. FAE17

“…This strain of Ascomycota sp. FAE17 was cultured on potato dextrose agar medium at 28 • C. After 10 days, the agar plugs were cut into small pieces to incubate on solid rice medium in 1000 mL Erlenmeyer flasks (90 g rice and 120 mL water for each Erlenmeyer flask, the total weight of rice was 27 kg) to culture for further 60 days at 28 • C [20]. The fermented cultures of Ascomycota sp.…”

“…In the course of further development and utilization of the pharmaceutical plant source of S. formosa , our previous investigation on endophytic fungi from this plant resulted in the discovery of several types of new compounds [ 20 ]. In this study, we investigated the endophytic fungus Ascomycota sp.…”

“…In the course of further development and utilization of the pharmaceutical plant source of S. formosa, our previous investigation on endophytic fungi from this plant resulted in the discovery of several types of new compounds [20]. In this study, we investigated the In the course of further development and utilization of the pharmaceutical plan source of S. formosa, our previous investigation on endophytic fungi from this plant re sulted in the discovery of several types of new compounds [20]. In this study, we investi gated the endophytic fungus Ascomycota sp.…”