Study on the Relationship Between Serum Iodine and Thyroid Dysfunctions: a Cross-Sectional Study

Xu, Tingting; Guo, Wenxing; Ren, Zhiyuan; H, Wei; Tan, Lei; Zhang, Wanqi

doi:10.1007/s12011-022-03459-1

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…We found that SIC has a good diagnostic value for thyroid diseases, and its accuracy is higher than that of UI. The results of this study are similar to other studies (47,52). Therefore, SIC is a reflection of thyroid function, and maintaining SIC within the normal range is beneficial to thyroid health.…”

Section: Discussionsupporting

confidence: 90%

Serum iodine concentration and its associations with thyroid function and dietary iodine in pregnant women in the southeast coast of China: a cross-sectional study

Ji,

Wu,

et al. 2023

Front. Endocrinol.

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BackgroundIodine deficiency is a major public health problem in pregnant women. Serum iodine (SI) may represent a useful biomarker for iodine nutrition evaluation. We aimed to assess the relationship between serum iodine concentration (SIC) and urinary iodine concentration (UIC), dietary iodine, thyroid function, and thyroid diseases in pregnant women in the southeast coast of China, and to provide a normal reference range of SIC for pregnant women.MethodsA multistage random sampling method was used to select the study population. We collected urine and blood samples from pregnant women and determined UIC and SIC as well as thyroid function using Arsenic-Cerium Catalytic Spectrophotometry, inductively coupled plasma mass spectrometry, and Beckman Coulter Access2 chemiluminescent immunoanalyzer and kit, respectively, and administered a questionnaire on dietary iodine intake in pregnant women.ResultsThere was a significant negative correlation between SI and thyroid-stimulating hormone (TSH) (r = −0.141) and a significant positive correlation between SI and free triiodothyronine (FT3) (r = 0.106), free thyroxine (FT4) (r = 0.236), triiodothyronine (TT3) (r = 0.229), total thyroxine (TT4) (r = 0.433), and dietary iodine intake (r = 0.068). There was a significant difference in SI levels of pregnancy between the second (78.13 μg/L) and third trimester (75.37 μg/L) (p = 0.018). SI levels between inadequate intake (74.58 μg/L) and appropriate intake (77.92 μg/L) groups were statistically different (p = 0.036). Low SIC was a risk factor for the development of hypothyroxinemia (adjusted OR = 3.14, 95% confidence interval: 1.75–5.66). The reference range for SIC in normal pregnant women is 45.03–112.44 μg/L.ConclusionSI may be a composite indicator of iodine nutritional status and thyroid function.

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Section: Discussionsupporting

confidence: 90%

Serum iodine concentration and its associations with thyroid function and dietary iodine in pregnant women in the southeast coast of China: a cross-sectional study

Ji,

Wu,

et al. 2023

Front. Endocrinol.

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“…However, urinary iodine levels can vary signi cantly on a daily basis and may not accurately re ect an individual's iodine nutritional status over an extended period of time [31]. Particularly in the context of AITD, there is a need for an indicator that can re ect recent iodine nutritional status, and serum iodine serves as an excellent alternative [32]. Dietary iodine is primarily absorbed in the small intestine and enters the bloodstream through the NIS transporter [33].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Correlation Between Varied Serum Iodine Nutritional Levels and Anti-Thyroglobulin Antibodies

Song,

Xu,

Wang

et al. 2024

Preprint

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Objective Iodine deficiency results in elevated thyroglobulin (Tg) concentrations, with high iodine Tg being more immunogenic than low iodine Tg. The study investigated the correlation between serum iodine concentration and thyroglobulin autoantibody (TgAb) levels across diverse iodine nutritional statuses as determined by urine iodine concentration (UIC). Methods Demographic information was collected from 1,482 participants through a questionnaire. Blood and spot urine were collected to measure thyroid-stimulating hormone (TSH), TgAb, thyroid anti-peroxidase antibody (TPOAb), serum iodine (SIC), serum non-protein-bound iodine (snPBI), urine iodine (UIC), creatinine (UCr). Results The median UIC and SIC were 146.5 µg/L and 74.9 µg/L, respectively. A linear relationship was observed between SIC, snPBI, and serum-protein-bound iodine (sPBI) (P < 0.001). The 90% reference intervals for SIC, snPBI, and sPBI were 50.7-120.7 µg/L, 21.9–52.9 µg/L, and 19.7–77.9 µg/L, respectively. The prevalence of elevated TgAb levels was significantly higher in women than in men (P < 0.001). Both low and high levels of snPBI and sPBI were associated with an increased risk of elevated TgAb levels. In women, the risk of positive TgAb in the group below the reference value of snPBI (OR = 2.079, 95%CI: 1.166, 3.705) and sPBI (OR = 2.578, 95%CI: 1.419, 4.684) was higher. In men, the risk of positive TgAb in the group below the reference value of StI was higher (OR = 3.395, 95%CI: 1.286, 8.962). Conclusion Iodine might exert an influence on TgAb levels through its binding to proteins, primarily Tg, thereby altering the iodine content of Tg. The interplay of gender factors further enhanced the risk of TgAb emergence.

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“…Particularly in the context of AITD, there is a need for an indicator that can re ect recent iodine nutritional status. Serum iodine serves as an excellent alternative [21]. Dietary iodine is primarily absorbed in the small intestine and enters the bloodstream through the NIS transporter [22].…”

Section: Discussionmentioning

confidence: 99%

Study on the relationship between serum iodine malnutrition and anti-thyroglobulin antibodies

Song,

Xu,

Wang

et al. 2023

Preprint

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Iodine deficiency results in elevated thyroglobulin (Tg) concentrations, with high iodine Tg being more immunogenic than low iodine Tg. This study aimed to investigate the relationship between serum iodine concentration and thyroglobulin autoantibody (TgAb) levels under different iodine nutritional statuses. Demographic information was collected from 1,482 participants through a questionnaire. Blood and spot urine were collected to measure thyroid-stimulating hormone (TSH), TgAb, thyroid anti-peroxidase antibody (TPOAb), total iodine (StI), serum non-protein-bound iodine (snPBI), urine iodine (UIC), creatinine (UCr). The median UIC and StI were 146.46 µg/L and 74.85 µg/L, respectively. A linear relationship was observed between StI, snPBI, and sPBI (P < 0.001). The 90% medical reference values for StI, snPBI, and sPBI were 50.74-120.66 µg/L, 21.86–52.87 µg/L, and 19.65–77.92 µg/L, respectively. The positive rate of TgAb was significantly higher in women than in men (P < 0.001). Both low and high levels of snPBI and sPBI were associated with an increased risk of elevated TgAb levels. In women, the risk of positive TgAb in the group below the reference value of snPBI (OR = 2.079, 95%CI: 1.166, 3.705) and sPBI (OR = 2.578, 95%CI: 1.419, 4.684) was higher. In men, the risk of positive TgAb in the group below the reference value of StI was higher (OR = 3.395, 95%CI: 1.286, 8.962). Iodine might influence TgAb levels by altering the iodine content of Tg, thus contributing to the development of autoimmune thyroid disorders.

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Study on the Relationship Between Serum Iodine and Thyroid Dysfunctions: a Cross-Sectional Study

Cited by 3 publications

References 32 publications

Serum iodine concentration and its associations with thyroid function and dietary iodine in pregnant women in the southeast coast of China: a cross-sectional study

Serum iodine concentration and its associations with thyroid function and dietary iodine in pregnant women in the southeast coast of China: a cross-sectional study

Exploring the Correlation Between Varied Serum Iodine Nutritional Levels and Anti-Thyroglobulin Antibodies

Study on the relationship between serum iodine malnutrition and anti-thyroglobulin antibodies

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