Study on the molecular structure and thermal stability of purine nucleoside analogs

Photophysical and Electrical Properties of Highly Luminescent 2/6-Triazolyl-Substituted Push–Pull Purines

“…The presence of N -heterocyclic molecular fragments has often been linked to a reduced thermal and chemical stability of the corresponding molecules. , Thermogravimetric analysis was performed to evaluate the thermal stability of the compounds 5d and 9d (Figure S1). The results show that both the molecules possess good thermal stability with the corresponding decomposition temperatures of 298 and 258 °C.…”

Planning Implications Related to Sterilization-Sensitive Science Investigations Associated with Mars Sample Return (MSR)

“…Isolated RNA molecules can denature at temperatures as low as 20°C, and free DNA can denature at 90°C (Wang et al, 2014). Individual nucleobases may be able to survive to temperatures as high as 200°C (Wang and You, 2015). However, neither DNA nor RNA is likely to survive dry heat sterilization intact.…”

“…Amino acids will start to decompose by thermal decarboxylation in the solid state at temperatures above 150°C (Rodante, 1992). N-glycosidic bond fracture and amine group oxidation of purine nucleosides occur at temperatures >200°C (Wang and You, 2015), and rapid -DNA strand breakage was observed at a temperature of 250°C (Glavin et al, 2002). Analysis of amino acids extracted from a Murchison meteorite residue after heating the meteorite in a tube furnace to a peak temperature of 220°C for ~ 1 minute showed that over 50% of the amino acids were destroyed during heating (Glavin and Bada, 2001).…”

Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies

“…This resistance to high temperature could be explained by the chemical structure of TIC, which consists of a purine nucleoside core, which is known to possess a high thermal resistance [32]. Moreover, other groups are present which can resist high temperatures relatively easily such as the aryl ring, OH,and NH, of which the latter two also form strong intermolecular hydrogen bonds that are difficult to break [33].…”