Study on the Model for Regulation of the Allosteric Enzyme Activity

Li, Qian‐Zhong; Luo, Liaofu; Zhang, Lirong

doi:10.1002/cjoc.20020201209

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…20,21 Employing nanoparticles as building blocks offers a powerful tool to succeed in fabrication of desired 1-3 D (dimensional) nanoarchitectures of Co 3 O 4 . 9,22,23 Its nanostructures with a great variety of morphologies, such as nanocubes, 24,25 nanorods, 7,26 nanowires, 27,28 nanotubes, 10,29 nanobelts, 30,31 nanospheres, 14,32 nanosheets, 33,34 nanomeshs, 35 nanooctahedra, 36 and nanocapsules, 37 etc., have been fabricated. Further investigations discovered that there is a close correlation between shape/morphology and performances of Co 3 O 4 nanocrystals in practical applications.…”

Section: Introductionmentioning

confidence: 99%

Co3O4 nanocrystals with predominantly exposed facets: synthesis, environmental and energy applications

et al. 2013

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His research interests include visible light photocatalysis, solar fuels, solar cells and environmental remediation using nanostructured metal oxides and emerging nanocarbons. He has published more than 50 refereed journal papers with over 500 citations. Prof. Ha Ming Ang obtained his PhD from University College London in the 1970s. His research interests include development, characterisation and application of nanostructured materials for use as photocatalysts for treatment of contaminants present in both liquids and gases. He has published over 100 refereed papers in reputed international journals.

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Section: Introductionmentioning

confidence: 99%

Co3O4 nanocrystals with predominantly exposed facets: synthesis, environmental and energy applications

et al. 2013

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“…[3,[14][15][16][17] It has been reported that significant conformational variations could be identified in a variety of protein-ligand interactions and can be generally attributed as allosteric transitions of proteins. [18][19][20][21][22][23][24] The mechanisms of corresponding conformational and micro-environmental changes could provide new venues for pharmacological studies of drug ligands. [14,25] Non-the HSA molecules are preferred for developing strategies of affinity-controlled release.…”

Section: Introductionmentioning

confidence: 99%

Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand

Hou

Peng

et al. 2017

Chin. J. Chem.

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Human serum albumin (HSA) is an abundant protein in plasma that can bind and transport many small molecules, and the corresponding affinity-controlled drug delivery shows great advantage in the biological system. Peptide SA06 is a reported ligand comprising 20 amino acids, and is known to non-covalently bind with HSA to extend the lifetime and improve the pharmacokinetic performance. The structural information of the HSA-peptide complex is keen for obtaining molecular insight of the binding mechanism. We studied the secondary structural change and structure-affinity relations of Peptide SA06 with HSA by using circular dichroism (CD) spectroscopy in solution. Noticeable allosteric effect can be identified by compositional increase of α-helix structures when the peptide was co-incubated with HSA. Furthermore, the equilibrium dissociation constant of Peptide SA06 with HSA can be determined by CD-based method. This work provides structural evidence on the allosteric interaction between peptide ligand and HSA, and sheds light on optimization of therapeutic properties in the affinity-controlled delivery systems.Keywords human serum albumin, peptide ligands, allosteric modulation, structure-affinity relations, affinity-controlled delivery covalent interactions (electrostatic, hydrophobic, and Van der Waals) between the therapeutic components and

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Study on the Model for Regulation of the Allosteric Enzyme Activity

Abstract: Keywords ity , h-i c effect, activator molecule, repressive molecule d&c enzyme, coopedvity and anticwperetiv-*

Cited by 2 publications

References 18 publications

Co3O4 nanocrystals with predominantly exposed facets: synthesis, environmental and energy applications

Co3O4 nanocrystals with predominantly exposed facets: synthesis, environmental and energy applications

Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand

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